Does the number of abnormal nodes in the axilla correlate with likelihood of response to neoadjuvant chemotherapy?
Association of Breast Surgery ePoster Library. Micha A. 05/15/17; 166220; P017
Ms. Aikaterini Micha
REGULAR CONTENT
Login now to access Regular content available to all registered users.
Abstract
Rate & Comment (0)
Introduction
Neoadjuvant chemotherapy (NACT) is an established pathway in the management of breast cancer. Axillary clearance is the standard treatment for patients with proven axillary involvement at diagnosis. The rates of pathological complete response (pCR) in the axilla are more than 60% in Her2 positive cancers, hence there is a move to consider axillary conservation in those with a high likelihood of pCR in the axilla. The aim of this study was to examine whether the rate of pCR varies according to the number of radiologically suspicious nodes at diagnosis.
Methods
Electronic patient records from patients with proven axillary involvement treated with NACT between 2007 and 2015 were examined. Data about patient age, tumour type and receptor status, number of radiologically suspicious nodes, treatment regimen, and clinical, radiological and pathological complete response were collected. Results were divided according to the number of suspicious nodes on the baseline ultrasound scan. Chi-squared test was used to compare pCR rates.
Results
A total of 297 patients with proven axillary disease were treated with NACT. 34% were Her2 positive and 66% were Her2 negative. 101 patients had one suspicious lymph node on initial ultrasound scan, 50 had 2 suspicious nodes and 146 patients had more than 2 suspicious nodes. Of those, 41%, 38% and 32% respectively achieved a pCR in the axilla. No association was found between the number of suspicious lymph nodes on baseline ultrasound scan and the rate of pCR in the axilla (p=0.381).
Conclusion
The number of suspicious nodes identified does not seem to affect pCR. It is important not to exclude women with larger numbers of abnormal-looking nodes from a more conservative approach, especially if they have a phenotype, such as Her2 positive, which is likely to attain a good response to NACT.
Neoadjuvant chemotherapy (NACT) is an established pathway in the management of breast cancer. Axillary clearance is the standard treatment for patients with proven axillary involvement at diagnosis. The rates of pathological complete response (pCR) in the axilla are more than 60% in Her2 positive cancers, hence there is a move to consider axillary conservation in those with a high likelihood of pCR in the axilla. The aim of this study was to examine whether the rate of pCR varies according to the number of radiologically suspicious nodes at diagnosis.
Methods
Electronic patient records from patients with proven axillary involvement treated with NACT between 2007 and 2015 were examined. Data about patient age, tumour type and receptor status, number of radiologically suspicious nodes, treatment regimen, and clinical, radiological and pathological complete response were collected. Results were divided according to the number of suspicious nodes on the baseline ultrasound scan. Chi-squared test was used to compare pCR rates.
Results
A total of 297 patients with proven axillary disease were treated with NACT. 34% were Her2 positive and 66% were Her2 negative. 101 patients had one suspicious lymph node on initial ultrasound scan, 50 had 2 suspicious nodes and 146 patients had more than 2 suspicious nodes. Of those, 41%, 38% and 32% respectively achieved a pCR in the axilla. No association was found between the number of suspicious lymph nodes on baseline ultrasound scan and the rate of pCR in the axilla (p=0.381).
Conclusion
The number of suspicious nodes identified does not seem to affect pCR. It is important not to exclude women with larger numbers of abnormal-looking nodes from a more conservative approach, especially if they have a phenotype, such as Her2 positive, which is likely to attain a good response to NACT.
Introduction
Neoadjuvant chemotherapy (NACT) is an established pathway in the management of breast cancer. Axillary clearance is the standard treatment for patients with proven axillary involvement at diagnosis. The rates of pathological complete response (pCR) in the axilla are more than 60% in Her2 positive cancers, hence there is a move to consider axillary conservation in those with a high likelihood of pCR in the axilla. The aim of this study was to examine whether the rate of pCR varies according to the number of radiologically suspicious nodes at diagnosis.
Methods
Electronic patient records from patients with proven axillary involvement treated with NACT between 2007 and 2015 were examined. Data about patient age, tumour type and receptor status, number of radiologically suspicious nodes, treatment regimen, and clinical, radiological and pathological complete response were collected. Results were divided according to the number of suspicious nodes on the baseline ultrasound scan. Chi-squared test was used to compare pCR rates.
Results
A total of 297 patients with proven axillary disease were treated with NACT. 34% were Her2 positive and 66% were Her2 negative. 101 patients had one suspicious lymph node on initial ultrasound scan, 50 had 2 suspicious nodes and 146 patients had more than 2 suspicious nodes. Of those, 41%, 38% and 32% respectively achieved a pCR in the axilla. No association was found between the number of suspicious lymph nodes on baseline ultrasound scan and the rate of pCR in the axilla (p=0.381).
Conclusion
The number of suspicious nodes identified does not seem to affect pCR. It is important not to exclude women with larger numbers of abnormal-looking nodes from a more conservative approach, especially if they have a phenotype, such as Her2 positive, which is likely to attain a good response to NACT.
Neoadjuvant chemotherapy (NACT) is an established pathway in the management of breast cancer. Axillary clearance is the standard treatment for patients with proven axillary involvement at diagnosis. The rates of pathological complete response (pCR) in the axilla are more than 60% in Her2 positive cancers, hence there is a move to consider axillary conservation in those with a high likelihood of pCR in the axilla. The aim of this study was to examine whether the rate of pCR varies according to the number of radiologically suspicious nodes at diagnosis.
Methods
Electronic patient records from patients with proven axillary involvement treated with NACT between 2007 and 2015 were examined. Data about patient age, tumour type and receptor status, number of radiologically suspicious nodes, treatment regimen, and clinical, radiological and pathological complete response were collected. Results were divided according to the number of suspicious nodes on the baseline ultrasound scan. Chi-squared test was used to compare pCR rates.
Results
A total of 297 patients with proven axillary disease were treated with NACT. 34% were Her2 positive and 66% were Her2 negative. 101 patients had one suspicious lymph node on initial ultrasound scan, 50 had 2 suspicious nodes and 146 patients had more than 2 suspicious nodes. Of those, 41%, 38% and 32% respectively achieved a pCR in the axilla. No association was found between the number of suspicious lymph nodes on baseline ultrasound scan and the rate of pCR in the axilla (p=0.381).
Conclusion
The number of suspicious nodes identified does not seem to affect pCR. It is important not to exclude women with larger numbers of abnormal-looking nodes from a more conservative approach, especially if they have a phenotype, such as Her2 positive, which is likely to attain a good response to NACT.
Code of conduct/disclaimer available in General Terms & Conditions
{{ help_message }}
{{filter}}