Safety of Autologous Fat Banking - A Report on the Regenerys Pilot Study: A pilot study to determine the safety and efficacy of autologous tissue banking in breast reconstruction following cancer excision.
Association of Breast Surgery ePoster Library. Bhaskar P. 05/15/17; 166225; P003
Mr. Pud Bhaskar
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Abstract
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Introduction
Lipomodelling in breast reconstruction often requires repeat procedures to achieve the required cosmetic outcome. Each procedure requires fat harvesting followed by re-injection into the breast. Associated morbidity is predominantly attributed to the harvesting process, causing pain, bruising, swelling, altered sensation, scarring and risk of damage to deeper structures. If larger fat volumes could be harvested and stored whilst retaining tissue quality, multiple lipomodelling sessions could be performed even under local anaesthetic, without repeated exposure to harvesting and general anaesthetic risks. This study aims to determine the safety and efficacy of storing fat for staged breast lipomodelling.
Methods
Following ethical approval, 31 patients enrolled across four institutions. Fat was harvested, processed and cryopreserved until required, whereupon it was thawed, washed and distributed. Data was collected prospectively regarding complications, fat viability and retention. Patients were followed up at six weeks, three months and six months.
Results
The re-injection procedures are summarised below. There were no documented complications at final follow up. Mean fat viabilities were 77% pre-storage and 78% post-storage. On clinical examination, fat retention from immediate and staged injection appeared comparable.
Conclusions
Banking of adipose tissue for staged breast lipomodelling is safe, with no increased complication risk. Fat viability is unaffected by storage. This staged fat transfer approach offers reduced patient risk and morbidity with comparable efficacy to traditional multiple harvest techniques.
Lipomodelling in breast reconstruction often requires repeat procedures to achieve the required cosmetic outcome. Each procedure requires fat harvesting followed by re-injection into the breast. Associated morbidity is predominantly attributed to the harvesting process, causing pain, bruising, swelling, altered sensation, scarring and risk of damage to deeper structures. If larger fat volumes could be harvested and stored whilst retaining tissue quality, multiple lipomodelling sessions could be performed even under local anaesthetic, without repeated exposure to harvesting and general anaesthetic risks. This study aims to determine the safety and efficacy of storing fat for staged breast lipomodelling.
Methods
Following ethical approval, 31 patients enrolled across four institutions. Fat was harvested, processed and cryopreserved until required, whereupon it was thawed, washed and distributed. Data was collected prospectively regarding complications, fat viability and retention. Patients were followed up at six weeks, three months and six months.
Results
The re-injection procedures are summarised below. There were no documented complications at final follow up. Mean fat viabilities were 77% pre-storage and 78% post-storage. On clinical examination, fat retention from immediate and staged injection appeared comparable.
Conclusions
Banking of adipose tissue for staged breast lipomodelling is safe, with no increased complication risk. Fat viability is unaffected by storage. This staged fat transfer approach offers reduced patient risk and morbidity with comparable efficacy to traditional multiple harvest techniques.
Introduction
Lipomodelling in breast reconstruction often requires repeat procedures to achieve the required cosmetic outcome. Each procedure requires fat harvesting followed by re-injection into the breast. Associated morbidity is predominantly attributed to the harvesting process, causing pain, bruising, swelling, altered sensation, scarring and risk of damage to deeper structures. If larger fat volumes could be harvested and stored whilst retaining tissue quality, multiple lipomodelling sessions could be performed even under local anaesthetic, without repeated exposure to harvesting and general anaesthetic risks. This study aims to determine the safety and efficacy of storing fat for staged breast lipomodelling.
Methods
Following ethical approval, 31 patients enrolled across four institutions. Fat was harvested, processed and cryopreserved until required, whereupon it was thawed, washed and distributed. Data was collected prospectively regarding complications, fat viability and retention. Patients were followed up at six weeks, three months and six months.
Results
The re-injection procedures are summarised below. There were no documented complications at final follow up. Mean fat viabilities were 77% pre-storage and 78% post-storage. On clinical examination, fat retention from immediate and staged injection appeared comparable.
Conclusions
Banking of adipose tissue for staged breast lipomodelling is safe, with no increased complication risk. Fat viability is unaffected by storage. This staged fat transfer approach offers reduced patient risk and morbidity with comparable efficacy to traditional multiple harvest techniques.
Lipomodelling in breast reconstruction often requires repeat procedures to achieve the required cosmetic outcome. Each procedure requires fat harvesting followed by re-injection into the breast. Associated morbidity is predominantly attributed to the harvesting process, causing pain, bruising, swelling, altered sensation, scarring and risk of damage to deeper structures. If larger fat volumes could be harvested and stored whilst retaining tissue quality, multiple lipomodelling sessions could be performed even under local anaesthetic, without repeated exposure to harvesting and general anaesthetic risks. This study aims to determine the safety and efficacy of storing fat for staged breast lipomodelling.
Methods
Following ethical approval, 31 patients enrolled across four institutions. Fat was harvested, processed and cryopreserved until required, whereupon it was thawed, washed and distributed. Data was collected prospectively regarding complications, fat viability and retention. Patients were followed up at six weeks, three months and six months.
Results
The re-injection procedures are summarised below. There were no documented complications at final follow up. Mean fat viabilities were 77% pre-storage and 78% post-storage. On clinical examination, fat retention from immediate and staged injection appeared comparable.
Conclusions
Banking of adipose tissue for staged breast lipomodelling is safe, with no increased complication risk. Fat viability is unaffected by storage. This staged fat transfer approach offers reduced patient risk and morbidity with comparable efficacy to traditional multiple harvest techniques.
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