Decreased expressionof BRCA2 accelerates sporadic breast cancer progression: a study in Indian population
Association of Breast Surgery ePoster Library. Sarkar D. 05/15/17; 166236; P161
Prof. Dr. Diptendra Kumar Sarkar
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Abstract
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Introduction : BRCA2 is a mismatch repair gene. Germ line mutation in BRCA predisposes individuals to familial breast and ovarian cancers.
Aims: To study the implication of BRCA2 expression in cases of sporadic breast cancer.
Study design : Female breast cancer aged between 20 and 75 years were selected for study.Patients with stage IV disease or previous history of any non breast malignancy or undergoing neoadjuvant therapy were excluded.Concentration of BRCA2 was measured by sandwiched method of ELISA.IHC was done to determine the hormone receptor and HER2 neu status.The results were correlated with age, menopausal stutus,clinical stage,size,lymph node status,grade, histopathological subtype and molecular subtypes.Statistical analysis and significance were ascertained using SPSS (Chi-square test)
Results : The findings were noted. Age(p=0.9640),menopausal status(0.6282),Tumour size(p=0.1226),HP (p=0.3977) insignificantly correlated with BRCA2 data. Clinical stage(p=0.0112),Lymph node status(p=0.0055),Grade (p=0.0030) and molecular subtypes(p=0.0010) were found to have significant association.
Conclusion : Decreased expression of BRCA2 was found to be mostly triple negative cancers and had aggressive biological nature. The study highlights the fact that Indian population of breast cancer has higher incidence of BRCA2 mutation and is possibly one of the reasons for a younger breast cancer with poorer outcome
Aims: To study the implication of BRCA2 expression in cases of sporadic breast cancer.
Study design : Female breast cancer aged between 20 and 75 years were selected for study.Patients with stage IV disease or previous history of any non breast malignancy or undergoing neoadjuvant therapy were excluded.Concentration of BRCA2 was measured by sandwiched method of ELISA.IHC was done to determine the hormone receptor and HER2 neu status.The results were correlated with age, menopausal stutus,clinical stage,size,lymph node status,grade, histopathological subtype and molecular subtypes.Statistical analysis and significance were ascertained using SPSS (Chi-square test)
Results : The findings were noted. Age(p=0.9640),menopausal status(0.6282),Tumour size(p=0.1226),HP (p=0.3977) insignificantly correlated with BRCA2 data. Clinical stage(p=0.0112),Lymph node status(p=0.0055),Grade (p=0.0030) and molecular subtypes(p=0.0010) were found to have significant association.
Conclusion : Decreased expression of BRCA2 was found to be mostly triple negative cancers and had aggressive biological nature. The study highlights the fact that Indian population of breast cancer has higher incidence of BRCA2 mutation and is possibly one of the reasons for a younger breast cancer with poorer outcome
Introduction : BRCA2 is a mismatch repair gene. Germ line mutation in BRCA predisposes individuals to familial breast and ovarian cancers.
Aims: To study the implication of BRCA2 expression in cases of sporadic breast cancer.
Study design : Female breast cancer aged between 20 and 75 years were selected for study.Patients with stage IV disease or previous history of any non breast malignancy or undergoing neoadjuvant therapy were excluded.Concentration of BRCA2 was measured by sandwiched method of ELISA.IHC was done to determine the hormone receptor and HER2 neu status.The results were correlated with age, menopausal stutus,clinical stage,size,lymph node status,grade, histopathological subtype and molecular subtypes.Statistical analysis and significance were ascertained using SPSS (Chi-square test)
Results : The findings were noted. Age(p=0.9640),menopausal status(0.6282),Tumour size(p=0.1226),HP (p=0.3977) insignificantly correlated with BRCA2 data. Clinical stage(p=0.0112),Lymph node status(p=0.0055),Grade (p=0.0030) and molecular subtypes(p=0.0010) were found to have significant association.
Conclusion : Decreased expression of BRCA2 was found to be mostly triple negative cancers and had aggressive biological nature. The study highlights the fact that Indian population of breast cancer has higher incidence of BRCA2 mutation and is possibly one of the reasons for a younger breast cancer with poorer outcome
Aims: To study the implication of BRCA2 expression in cases of sporadic breast cancer.
Study design : Female breast cancer aged between 20 and 75 years were selected for study.Patients with stage IV disease or previous history of any non breast malignancy or undergoing neoadjuvant therapy were excluded.Concentration of BRCA2 was measured by sandwiched method of ELISA.IHC was done to determine the hormone receptor and HER2 neu status.The results were correlated with age, menopausal stutus,clinical stage,size,lymph node status,grade, histopathological subtype and molecular subtypes.Statistical analysis and significance were ascertained using SPSS (Chi-square test)
Results : The findings were noted. Age(p=0.9640),menopausal status(0.6282),Tumour size(p=0.1226),HP (p=0.3977) insignificantly correlated with BRCA2 data. Clinical stage(p=0.0112),Lymph node status(p=0.0055),Grade (p=0.0030) and molecular subtypes(p=0.0010) were found to have significant association.
Conclusion : Decreased expression of BRCA2 was found to be mostly triple negative cancers and had aggressive biological nature. The study highlights the fact that Indian population of breast cancer has higher incidence of BRCA2 mutation and is possibly one of the reasons for a younger breast cancer with poorer outcome
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