Contralateral breast cancer in Northern Ireland: A retrospective review from 1993 to 2016.
Association of Breast Surgery ePoster Library. McIlmunn C. 05/15/17; 166323; P026
Mr. Colin McIlmunn
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Abstract
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Background
The incidence of contralateral breast cancer (CBC), (defined as a second primary breast cancer occurring in the other breast more than six months after an initial index tumour diagnosis) is reported as 0.4-0.7% per year, equating to 11-16% in the 20 years following initial diagnosis. CBC is the most common second malignancy to occur in these women.
Aim
This study aims to identify the incidence and characteristics of CBC in Northern Ireland (NI) over the period 1993-2016. The NI Cancer Registry was searched to identify all women with a CBC diagnosis over this period, and clinico-pathological data obtained for verified cases.
Results
463 CBC patients were identified. The median age at initial diagnosis was 57 (IQR 47-65). The median period between diagnoses was 7 years (IQR 3.9-10.9). Tumour morphology details were available for 366 (79%) CBC pairs. 262 index tumours were ductal, 15 lobular, 16 mixed and 2 other. 295 (81%) of the tumour pairs shared similar morphology. ER status was available for 273 tumour pairs. Of these, 209 (77%) index tumours were positive and positive ER status was concordant in 157 (75%) cases, ER negativity was concordant in 42% of ER negative index tumour cases.
Conclusion
In conclusion this study provides important data on the incidence of CBC in NI. This patient cohort will provide a valuable resource for further study of the relationships between primary and CBCs, and to identify potential risk factors or predictive biomarkers for CBC to guide appropriate surgical management.
The incidence of contralateral breast cancer (CBC), (defined as a second primary breast cancer occurring in the other breast more than six months after an initial index tumour diagnosis) is reported as 0.4-0.7% per year, equating to 11-16% in the 20 years following initial diagnosis. CBC is the most common second malignancy to occur in these women.
Aim
This study aims to identify the incidence and characteristics of CBC in Northern Ireland (NI) over the period 1993-2016. The NI Cancer Registry was searched to identify all women with a CBC diagnosis over this period, and clinico-pathological data obtained for verified cases.
Results
463 CBC patients were identified. The median age at initial diagnosis was 57 (IQR 47-65). The median period between diagnoses was 7 years (IQR 3.9-10.9). Tumour morphology details were available for 366 (79%) CBC pairs. 262 index tumours were ductal, 15 lobular, 16 mixed and 2 other. 295 (81%) of the tumour pairs shared similar morphology. ER status was available for 273 tumour pairs. Of these, 209 (77%) index tumours were positive and positive ER status was concordant in 157 (75%) cases, ER negativity was concordant in 42% of ER negative index tumour cases.
Conclusion
In conclusion this study provides important data on the incidence of CBC in NI. This patient cohort will provide a valuable resource for further study of the relationships between primary and CBCs, and to identify potential risk factors or predictive biomarkers for CBC to guide appropriate surgical management.
Background
The incidence of contralateral breast cancer (CBC), (defined as a second primary breast cancer occurring in the other breast more than six months after an initial index tumour diagnosis) is reported as 0.4-0.7% per year, equating to 11-16% in the 20 years following initial diagnosis. CBC is the most common second malignancy to occur in these women.
Aim
This study aims to identify the incidence and characteristics of CBC in Northern Ireland (NI) over the period 1993-2016. The NI Cancer Registry was searched to identify all women with a CBC diagnosis over this period, and clinico-pathological data obtained for verified cases.
Results
463 CBC patients were identified. The median age at initial diagnosis was 57 (IQR 47-65). The median period between diagnoses was 7 years (IQR 3.9-10.9). Tumour morphology details were available for 366 (79%) CBC pairs. 262 index tumours were ductal, 15 lobular, 16 mixed and 2 other. 295 (81%) of the tumour pairs shared similar morphology. ER status was available for 273 tumour pairs. Of these, 209 (77%) index tumours were positive and positive ER status was concordant in 157 (75%) cases, ER negativity was concordant in 42% of ER negative index tumour cases.
Conclusion
In conclusion this study provides important data on the incidence of CBC in NI. This patient cohort will provide a valuable resource for further study of the relationships between primary and CBCs, and to identify potential risk factors or predictive biomarkers for CBC to guide appropriate surgical management.
The incidence of contralateral breast cancer (CBC), (defined as a second primary breast cancer occurring in the other breast more than six months after an initial index tumour diagnosis) is reported as 0.4-0.7% per year, equating to 11-16% in the 20 years following initial diagnosis. CBC is the most common second malignancy to occur in these women.
Aim
This study aims to identify the incidence and characteristics of CBC in Northern Ireland (NI) over the period 1993-2016. The NI Cancer Registry was searched to identify all women with a CBC diagnosis over this period, and clinico-pathological data obtained for verified cases.
Results
463 CBC patients were identified. The median age at initial diagnosis was 57 (IQR 47-65). The median period between diagnoses was 7 years (IQR 3.9-10.9). Tumour morphology details were available for 366 (79%) CBC pairs. 262 index tumours were ductal, 15 lobular, 16 mixed and 2 other. 295 (81%) of the tumour pairs shared similar morphology. ER status was available for 273 tumour pairs. Of these, 209 (77%) index tumours were positive and positive ER status was concordant in 157 (75%) cases, ER negativity was concordant in 42% of ER negative index tumour cases.
Conclusion
In conclusion this study provides important data on the incidence of CBC in NI. This patient cohort will provide a valuable resource for further study of the relationships between primary and CBCs, and to identify potential risk factors or predictive biomarkers for CBC to guide appropriate surgical management.
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