Safety of radiotherapy omission in older women with good prognosis breast cancer following breast-conserving surgery
Association of Breast Surgery ePoster Library. Rashid S. 05/15/17; 166325; P105
Ms. Sameena Rashid
REGULAR CONTENT
Login now to access Regular content available to all registered users.
Abstract
Rate & Comment (0)
Introduction: The benefit of radiotherapy in older women with good prognosis breast cancer treated with breast-conserving surgery has been controversial. SIGN guidelines recommend it be considered in all patients undergoing breast-conserving surgery. However, there are studies supporting treatment of low-risk older patients with surgery and hormone therapy alone. In the PRIME II trial, a low local relapse rate at 5 years was reported. Within our practice we have identified a cohort of patients in which radiotherapy was omitted and our aim was to evaluate the effect of this on recurrence and mortality rates.
Methods: Electronic records of patients who underwent breast-conserving surgery and did not receive radiotherapy were reviewed.
Results: 493 patients underwent breast-conserving surgery. 52 (10.5%) had no radiotherapy. Average age was 71 (range 26-91). Average follow up was 32 months (range 17-51). 22(42.3%) had a recorded MDT discussion. 14 (27%) were omitted due to age and good prognosis, 26 (50%) were unfit, 11(21%) declined and 1(1.9%) had previous radiotherapy. Recurrence rate was 17% (n=9) with ipsilateral local recurrence 8% (n=4), regional recurrence 4% (n=2), distant metastasis in 6% (n=3). 18 patients (35%) died, 3(19%) with metastatic breast cancer. 26 patients (50%) met PRIME II criteria of which 3(0.1%) had local recurrence.
Conclusions: Omitting adjuvant radiotherapy in elderly women with good prognosis cancer can be justified on the basis of the low risk of locoregional recurrence.
Methods: Electronic records of patients who underwent breast-conserving surgery and did not receive radiotherapy were reviewed.
Results: 493 patients underwent breast-conserving surgery. 52 (10.5%) had no radiotherapy. Average age was 71 (range 26-91). Average follow up was 32 months (range 17-51). 22(42.3%) had a recorded MDT discussion. 14 (27%) were omitted due to age and good prognosis, 26 (50%) were unfit, 11(21%) declined and 1(1.9%) had previous radiotherapy. Recurrence rate was 17% (n=9) with ipsilateral local recurrence 8% (n=4), regional recurrence 4% (n=2), distant metastasis in 6% (n=3). 18 patients (35%) died, 3(19%) with metastatic breast cancer. 26 patients (50%) met PRIME II criteria of which 3(0.1%) had local recurrence.
Conclusions: Omitting adjuvant radiotherapy in elderly women with good prognosis cancer can be justified on the basis of the low risk of locoregional recurrence.
Introduction: The benefit of radiotherapy in older women with good prognosis breast cancer treated with breast-conserving surgery has been controversial. SIGN guidelines recommend it be considered in all patients undergoing breast-conserving surgery. However, there are studies supporting treatment of low-risk older patients with surgery and hormone therapy alone. In the PRIME II trial, a low local relapse rate at 5 years was reported. Within our practice we have identified a cohort of patients in which radiotherapy was omitted and our aim was to evaluate the effect of this on recurrence and mortality rates.
Methods: Electronic records of patients who underwent breast-conserving surgery and did not receive radiotherapy were reviewed.
Results: 493 patients underwent breast-conserving surgery. 52 (10.5%) had no radiotherapy. Average age was 71 (range 26-91). Average follow up was 32 months (range 17-51). 22(42.3%) had a recorded MDT discussion. 14 (27%) were omitted due to age and good prognosis, 26 (50%) were unfit, 11(21%) declined and 1(1.9%) had previous radiotherapy. Recurrence rate was 17% (n=9) with ipsilateral local recurrence 8% (n=4), regional recurrence 4% (n=2), distant metastasis in 6% (n=3). 18 patients (35%) died, 3(19%) with metastatic breast cancer. 26 patients (50%) met PRIME II criteria of which 3(0.1%) had local recurrence.
Conclusions: Omitting adjuvant radiotherapy in elderly women with good prognosis cancer can be justified on the basis of the low risk of locoregional recurrence.
Methods: Electronic records of patients who underwent breast-conserving surgery and did not receive radiotherapy were reviewed.
Results: 493 patients underwent breast-conserving surgery. 52 (10.5%) had no radiotherapy. Average age was 71 (range 26-91). Average follow up was 32 months (range 17-51). 22(42.3%) had a recorded MDT discussion. 14 (27%) were omitted due to age and good prognosis, 26 (50%) were unfit, 11(21%) declined and 1(1.9%) had previous radiotherapy. Recurrence rate was 17% (n=9) with ipsilateral local recurrence 8% (n=4), regional recurrence 4% (n=2), distant metastasis in 6% (n=3). 18 patients (35%) died, 3(19%) with metastatic breast cancer. 26 patients (50%) met PRIME II criteria of which 3(0.1%) had local recurrence.
Conclusions: Omitting adjuvant radiotherapy in elderly women with good prognosis cancer can be justified on the basis of the low risk of locoregional recurrence.
Code of conduct/disclaimer available in General Terms & Conditions
{{ help_message }}
{{filter}}