Bilateral synchronous breast cancer: histological concordance and surgical management
Association of Breast Surgery ePoster Library. Dobson G. 05/15/17; 166346; P142
Mr. Gary Dobson
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Abstract
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Introduction
Synchronous breast cancers (SBC) account for up to 3% of breast cancer diagnoses, and are often managed with bilateral mastectomy, although the optimal treatment strategy is unclear. We present initial findings of tumour morphology and surgical management of a cohort of SBC patients in Northern Ireland (NI).
Methods
Women with SBC diagnosed between 1992 - 2015 were identified from NI Cancer Registry data. Histopathology reports have been reviewed; pathological features of tumours and biomarker expression were collated. Data was collected on initial surgical treatment, and follow-up data was recorded where available.
Results
Data was available on 60 SBC cases between 1992 & 2015. Mean age at diagnosis was 59 years (range 32-91)
Fifty-two patients underwent surgical treatment: 35 patients had bilateral mastectomies, 12 underwent bilateral breast conserving surgery and the remainder a combination.
Conclusion
Bilateral mastectomy was confirmed to be the most common surgical treatment for SBCs. Half the tumours shared identical clinico-pathological features, suggesting either that SBC patients may have a propensity to develop tumours of a particular type, or that SBCs may be related. Genomic studies will be required to more clearly define these relationships. Comparison with matched controls will be necessary to determine whether SBCs have a worse prognosis than unilateral breast cancer, as suggested in the literature.
Synchronous breast cancers (SBC) account for up to 3% of breast cancer diagnoses, and are often managed with bilateral mastectomy, although the optimal treatment strategy is unclear. We present initial findings of tumour morphology and surgical management of a cohort of SBC patients in Northern Ireland (NI).
Methods
Women with SBC diagnosed between 1992 - 2015 were identified from NI Cancer Registry data. Histopathology reports have been reviewed; pathological features of tumours and biomarker expression were collated. Data was collected on initial surgical treatment, and follow-up data was recorded where available.
Results
Data was available on 60 SBC cases between 1992 & 2015. Mean age at diagnosis was 59 years (range 32-91)
Fifty-two patients underwent surgical treatment: 35 patients had bilateral mastectomies, 12 underwent bilateral breast conserving surgery and the remainder a combination.
Conclusion
Bilateral mastectomy was confirmed to be the most common surgical treatment for SBCs. Half the tumours shared identical clinico-pathological features, suggesting either that SBC patients may have a propensity to develop tumours of a particular type, or that SBCs may be related. Genomic studies will be required to more clearly define these relationships. Comparison with matched controls will be necessary to determine whether SBCs have a worse prognosis than unilateral breast cancer, as suggested in the literature.
Introduction
Synchronous breast cancers (SBC) account for up to 3% of breast cancer diagnoses, and are often managed with bilateral mastectomy, although the optimal treatment strategy is unclear. We present initial findings of tumour morphology and surgical management of a cohort of SBC patients in Northern Ireland (NI).
Methods
Women with SBC diagnosed between 1992 - 2015 were identified from NI Cancer Registry data. Histopathology reports have been reviewed; pathological features of tumours and biomarker expression were collated. Data was collected on initial surgical treatment, and follow-up data was recorded where available.
Results
Data was available on 60 SBC cases between 1992 & 2015. Mean age at diagnosis was 59 years (range 32-91)
Fifty-two patients underwent surgical treatment: 35 patients had bilateral mastectomies, 12 underwent bilateral breast conserving surgery and the remainder a combination.
Conclusion
Bilateral mastectomy was confirmed to be the most common surgical treatment for SBCs. Half the tumours shared identical clinico-pathological features, suggesting either that SBC patients may have a propensity to develop tumours of a particular type, or that SBCs may be related. Genomic studies will be required to more clearly define these relationships. Comparison with matched controls will be necessary to determine whether SBCs have a worse prognosis than unilateral breast cancer, as suggested in the literature.
Synchronous breast cancers (SBC) account for up to 3% of breast cancer diagnoses, and are often managed with bilateral mastectomy, although the optimal treatment strategy is unclear. We present initial findings of tumour morphology and surgical management of a cohort of SBC patients in Northern Ireland (NI).
Methods
Women with SBC diagnosed between 1992 - 2015 were identified from NI Cancer Registry data. Histopathology reports have been reviewed; pathological features of tumours and biomarker expression were collated. Data was collected on initial surgical treatment, and follow-up data was recorded where available.
Results
Data was available on 60 SBC cases between 1992 & 2015. Mean age at diagnosis was 59 years (range 32-91)
Fifty-two patients underwent surgical treatment: 35 patients had bilateral mastectomies, 12 underwent bilateral breast conserving surgery and the remainder a combination.
Conclusion
Bilateral mastectomy was confirmed to be the most common surgical treatment for SBCs. Half the tumours shared identical clinico-pathological features, suggesting either that SBC patients may have a propensity to develop tumours of a particular type, or that SBCs may be related. Genomic studies will be required to more clearly define these relationships. Comparison with matched controls will be necessary to determine whether SBCs have a worse prognosis than unilateral breast cancer, as suggested in the literature.
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