Can we predict further axillary nodal disease in patients with sentinel node macro metastases by OSNA in early breast cancer?
Association of Breast Surgery ePoster Library. Eley C. 05/15/17; 166353; P052
Dr. Catherine Eley
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Abstract
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Introduction: OSNA (One step nucleic Acid Amplification) is an intra-operative assessment which enables axillary node clearance in the presence of macro metastases. More than 50% of women who have axillary clearance do not have any further nodal involvement. We aimed to identify factors which can help to predict further axillary disease in the patients who have macro metastases to avoid unnecessary axillary clearance.
Method: A retrospective analysis of 995 consecutive patients with invasive breast carcinoma in a single centre from Nov. 2012 to Oct. 2016 was performed. All patients were clinically node negative pre-operatively, and underwent OSNA. Demographics, histopathological data and details of axillary management were analysed.
Results: Among 995 patients, 433 (43.5%) patients were node positive. 274(27.5%) patients had micro metastases and 159 (16%) had macro metastases. In the cohort with macro metastases, 118 (76%) patients proceeded to axillary node clearance. Of these, 58 patients had further axillary disease. Tumour size, presence of LVI, high KI-67 and high CK19 predicted for further axillary disease.
Conclusion: The tumour size, presence of LVI, high KI-67 and high ck19 predict further axillary disease.
Method: A retrospective analysis of 995 consecutive patients with invasive breast carcinoma in a single centre from Nov. 2012 to Oct. 2016 was performed. All patients were clinically node negative pre-operatively, and underwent OSNA. Demographics, histopathological data and details of axillary management were analysed.
Results: Among 995 patients, 433 (43.5%) patients were node positive. 274(27.5%) patients had micro metastases and 159 (16%) had macro metastases. In the cohort with macro metastases, 118 (76%) patients proceeded to axillary node clearance. Of these, 58 patients had further axillary disease. Tumour size, presence of LVI, high KI-67 and high CK19 predicted for further axillary disease.
Conclusion: The tumour size, presence of LVI, high KI-67 and high ck19 predict further axillary disease.
Introduction: OSNA (One step nucleic Acid Amplification) is an intra-operative assessment which enables axillary node clearance in the presence of macro metastases. More than 50% of women who have axillary clearance do not have any further nodal involvement. We aimed to identify factors which can help to predict further axillary disease in the patients who have macro metastases to avoid unnecessary axillary clearance.
Method: A retrospective analysis of 995 consecutive patients with invasive breast carcinoma in a single centre from Nov. 2012 to Oct. 2016 was performed. All patients were clinically node negative pre-operatively, and underwent OSNA. Demographics, histopathological data and details of axillary management were analysed.
Results: Among 995 patients, 433 (43.5%) patients were node positive. 274(27.5%) patients had micro metastases and 159 (16%) had macro metastases. In the cohort with macro metastases, 118 (76%) patients proceeded to axillary node clearance. Of these, 58 patients had further axillary disease. Tumour size, presence of LVI, high KI-67 and high CK19 predicted for further axillary disease.
Conclusion: The tumour size, presence of LVI, high KI-67 and high ck19 predict further axillary disease.
Method: A retrospective analysis of 995 consecutive patients with invasive breast carcinoma in a single centre from Nov. 2012 to Oct. 2016 was performed. All patients were clinically node negative pre-operatively, and underwent OSNA. Demographics, histopathological data and details of axillary management were analysed.
Results: Among 995 patients, 433 (43.5%) patients were node positive. 274(27.5%) patients had micro metastases and 159 (16%) had macro metastases. In the cohort with macro metastases, 118 (76%) patients proceeded to axillary node clearance. Of these, 58 patients had further axillary disease. Tumour size, presence of LVI, high KI-67 and high CK19 predicted for further axillary disease.
Conclusion: The tumour size, presence of LVI, high KI-67 and high ck19 predict further axillary disease.
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