Does the Total Tumour Load (TTL) as detected by One Step Nucleic Acid Amplification (OSNA) predict Non Sentinel Node Positivity?
Association of Breast Surgery ePoster Library. Pennick M. 05/13/19; 257050; P006
Mandana Pennick
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P006
Topic: Axilla
Introduction: It has been suggested that TTL can be used to predict non-sentinel node positivity in breast cancer by dividing patients into low(TTL4) and high risk categories (TTL>2.5x104). This is of increasing relevance as there is a move to more conservative axillary treatment in the post ACOSOG Z0011 era. Our objective was to test this theory for validity. Methods A retrospective review of all OSNA cases performed in Glan Clwyd hospital since 2015. Data collection included patient and tumour demographics, sentinel node results, total tumour load, non sentinel node involvement. ResultsEighty four OSNA procedures carried out on 80 patients, mean age 62 years. Tumour type 53(63%) IDC, 9(12%) ILC, 6(7%) Tubular, 3(4%) DCIS, 10(13%)others. Tumour grade1 8(9%), grade2 37(44%), grade3 36(43%), insitu 3(4%). Mean invasive size 25.7mm. Er positive 60(71%), negative 22(26%), unknown 3(4%); Pr positive 51(60%), negative 31(36%), unknown 3(4%); Her2 enriched 8(9%). Mean number sentinel nodes harvested 1.6 (range1-4); 20 patients had micrometastases, 21 patients had macrometastases, 19 patients had ANC. At ANC mean nodes excised 9.1(range5-14). TTL mean score 635076(range 260-5994620; median 10900).Non-sentinel node involvement in 47% of ANC cohort. Non-sentinel node involvement was seen in two thirds (66.6%) of high risk patients (TTL>2.5x104) as opposed to only 30% of those deemed low risk (pConclusionsTTL identified a high risk population in our cohort. We propose a multicentre study to confirm the findings.
Topic: Axilla
Introduction: It has been suggested that TTL can be used to predict non-sentinel node positivity in breast cancer by dividing patients into low(TTL4) and high risk categories (TTL>2.5x104). This is of increasing relevance as there is a move to more conservative axillary treatment in the post ACOSOG Z0011 era. Our objective was to test this theory for validity. Methods A retrospective review of all OSNA cases performed in Glan Clwyd hospital since 2015. Data collection included patient and tumour demographics, sentinel node results, total tumour load, non sentinel node involvement. ResultsEighty four OSNA procedures carried out on 80 patients, mean age 62 years. Tumour type 53(63%) IDC, 9(12%) ILC, 6(7%) Tubular, 3(4%) DCIS, 10(13%)others. Tumour grade1 8(9%), grade2 37(44%), grade3 36(43%), insitu 3(4%). Mean invasive size 25.7mm. Er positive 60(71%), negative 22(26%), unknown 3(4%); Pr positive 51(60%), negative 31(36%), unknown 3(4%); Her2 enriched 8(9%). Mean number sentinel nodes harvested 1.6 (range1-4); 20 patients had micrometastases, 21 patients had macrometastases, 19 patients had ANC. At ANC mean nodes excised 9.1(range5-14). TTL mean score 635076(range 260-5994620; median 10900).Non-sentinel node involvement in 47% of ANC cohort. Non-sentinel node involvement was seen in two thirds (66.6%) of high risk patients (TTL>2.5x104) as opposed to only 30% of those deemed low risk (pConclusionsTTL identified a high risk population in our cohort. We propose a multicentre study to confirm the findings.
P006
Topic: Axilla
Introduction: It has been suggested that TTL can be used to predict non-sentinel node positivity in breast cancer by dividing patients into low(TTL4) and high risk categories (TTL>2.5x104). This is of increasing relevance as there is a move to more conservative axillary treatment in the post ACOSOG Z0011 era. Our objective was to test this theory for validity. Methods A retrospective review of all OSNA cases performed in Glan Clwyd hospital since 2015. Data collection included patient and tumour demographics, sentinel node results, total tumour load, non sentinel node involvement. ResultsEighty four OSNA procedures carried out on 80 patients, mean age 62 years. Tumour type 53(63%) IDC, 9(12%) ILC, 6(7%) Tubular, 3(4%) DCIS, 10(13%)others. Tumour grade1 8(9%), grade2 37(44%), grade3 36(43%), insitu 3(4%). Mean invasive size 25.7mm. Er positive 60(71%), negative 22(26%), unknown 3(4%); Pr positive 51(60%), negative 31(36%), unknown 3(4%); Her2 enriched 8(9%). Mean number sentinel nodes harvested 1.6 (range1-4); 20 patients had micrometastases, 21 patients had macrometastases, 19 patients had ANC. At ANC mean nodes excised 9.1(range5-14). TTL mean score 635076(range 260-5994620; median 10900).Non-sentinel node involvement in 47% of ANC cohort. Non-sentinel node involvement was seen in two thirds (66.6%) of high risk patients (TTL>2.5x104) as opposed to only 30% of those deemed low risk (pConclusionsTTL identified a high risk population in our cohort. We propose a multicentre study to confirm the findings.
Topic: Axilla
Introduction: It has been suggested that TTL can be used to predict non-sentinel node positivity in breast cancer by dividing patients into low(TTL4) and high risk categories (TTL>2.5x104). This is of increasing relevance as there is a move to more conservative axillary treatment in the post ACOSOG Z0011 era. Our objective was to test this theory for validity. Methods A retrospective review of all OSNA cases performed in Glan Clwyd hospital since 2015. Data collection included patient and tumour demographics, sentinel node results, total tumour load, non sentinel node involvement. ResultsEighty four OSNA procedures carried out on 80 patients, mean age 62 years. Tumour type 53(63%) IDC, 9(12%) ILC, 6(7%) Tubular, 3(4%) DCIS, 10(13%)others. Tumour grade1 8(9%), grade2 37(44%), grade3 36(43%), insitu 3(4%). Mean invasive size 25.7mm. Er positive 60(71%), negative 22(26%), unknown 3(4%); Pr positive 51(60%), negative 31(36%), unknown 3(4%); Her2 enriched 8(9%). Mean number sentinel nodes harvested 1.6 (range1-4); 20 patients had micrometastases, 21 patients had macrometastases, 19 patients had ANC. At ANC mean nodes excised 9.1(range5-14). TTL mean score 635076(range 260-5994620; median 10900).Non-sentinel node involvement in 47% of ANC cohort. Non-sentinel node involvement was seen in two thirds (66.6%) of high risk patients (TTL>2.5x104) as opposed to only 30% of those deemed low risk (pConclusionsTTL identified a high risk population in our cohort. We propose a multicentre study to confirm the findings.
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