A Prospective Comparative Study Of Sentinel Lymph Node Biopsy With Indo-Cyanine Green (ICG) Florescence Technique versus Dual Dye Technique for Early Breast Cancer - Going Beyond the Horizon in India.
Association of Breast Surgery ePoster Library. Hassan Ali S. 05/13/19; 257054; P010
Shaziya Hassan Ali
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P010
Topic: Axilla
Introduction:The objective of the present study was toassess the performance of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) fluorescence method compared with that using theconventional method in detection of SLN. Methods :60 patients diagnosed with early breast cancer in a Tertiary cancer center (South India) underwent the SLNB procedure using technetium 99m radio colloid (R), methylene blue dye (MB), and ICG.All SLNs removed during surgery were labelled as hot, blue or/and fluorescent and sent for pathological examination.The detection rate of SLNs and positive SLNs, and the number of SLNs of ICG, MB+ R, ICG + MB, ICG + R were compared. Injection safety of ICG and MB was evaluated. Results: :SLN was identified in all 60 cases. Total SLNs removed was 145 (Mean=2). Identification rate with dual dye technique was 95%, blue dye alone 93.6%, radioisotope alone 96.8% whereas ICG alone was 100%. Both dual dye & ICG identified all the positive nodes (46.6%). None had any local or systemic reaction with ICG, 3 patients with blue dye had tattooing & skin staining. Conclusions: ICG is as effective as the dual dye for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled. It can be a boon for developing countries & second tier centers of developed country where there is limited access to nuclear medicine department facility & the cost involved in its establishment.
Topic: Axilla
Introduction:The objective of the present study was toassess the performance of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) fluorescence method compared with that using theconventional method in detection of SLN. Methods :60 patients diagnosed with early breast cancer in a Tertiary cancer center (South India) underwent the SLNB procedure using technetium 99m radio colloid (R), methylene blue dye (MB), and ICG.All SLNs removed during surgery were labelled as hot, blue or/and fluorescent and sent for pathological examination.The detection rate of SLNs and positive SLNs, and the number of SLNs of ICG, MB+ R, ICG + MB, ICG + R were compared. Injection safety of ICG and MB was evaluated. Results: :SLN was identified in all 60 cases. Total SLNs removed was 145 (Mean=2). Identification rate with dual dye technique was 95%, blue dye alone 93.6%, radioisotope alone 96.8% whereas ICG alone was 100%. Both dual dye & ICG identified all the positive nodes (46.6%). None had any local or systemic reaction with ICG, 3 patients with blue dye had tattooing & skin staining. Conclusions: ICG is as effective as the dual dye for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled. It can be a boon for developing countries & second tier centers of developed country where there is limited access to nuclear medicine department facility & the cost involved in its establishment.
P010
Topic: Axilla
Introduction:The objective of the present study was toassess the performance of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) fluorescence method compared with that using theconventional method in detection of SLN. Methods :60 patients diagnosed with early breast cancer in a Tertiary cancer center (South India) underwent the SLNB procedure using technetium 99m radio colloid (R), methylene blue dye (MB), and ICG.All SLNs removed during surgery were labelled as hot, blue or/and fluorescent and sent for pathological examination.The detection rate of SLNs and positive SLNs, and the number of SLNs of ICG, MB+ R, ICG + MB, ICG + R were compared. Injection safety of ICG and MB was evaluated. Results: :SLN was identified in all 60 cases. Total SLNs removed was 145 (Mean=2). Identification rate with dual dye technique was 95%, blue dye alone 93.6%, radioisotope alone 96.8% whereas ICG alone was 100%. Both dual dye & ICG identified all the positive nodes (46.6%). None had any local or systemic reaction with ICG, 3 patients with blue dye had tattooing & skin staining. Conclusions: ICG is as effective as the dual dye for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled. It can be a boon for developing countries & second tier centers of developed country where there is limited access to nuclear medicine department facility & the cost involved in its establishment.
Topic: Axilla
Introduction:The objective of the present study was toassess the performance of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) fluorescence method compared with that using theconventional method in detection of SLN. Methods :60 patients diagnosed with early breast cancer in a Tertiary cancer center (South India) underwent the SLNB procedure using technetium 99m radio colloid (R), methylene blue dye (MB), and ICG.All SLNs removed during surgery were labelled as hot, blue or/and fluorescent and sent for pathological examination.The detection rate of SLNs and positive SLNs, and the number of SLNs of ICG, MB+ R, ICG + MB, ICG + R were compared. Injection safety of ICG and MB was evaluated. Results: :SLN was identified in all 60 cases. Total SLNs removed was 145 (Mean=2). Identification rate with dual dye technique was 95%, blue dye alone 93.6%, radioisotope alone 96.8% whereas ICG alone was 100%. Both dual dye & ICG identified all the positive nodes (46.6%). None had any local or systemic reaction with ICG, 3 patients with blue dye had tattooing & skin staining. Conclusions: ICG is as effective as the dual dye for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled. It can be a boon for developing countries & second tier centers of developed country where there is limited access to nuclear medicine department facility & the cost involved in its establishment.
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