Vitamain D deficiency in mastalgia : is it a coincidence or an association ?
Association of Breast Surgery ePoster Library. Sarkar D. 05/13/19; 257072; P028
Prof. Dr. Diptendra Kumar Sarkar
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P028
Topic: Benign disease
Introduction:Mastalgia is the commonest reason for presentation of a female in a breast OPD. Various medicine and lifestyle modifications have been suggested with variable results. The role of Vitamin D in subtle regulation of estrogen-progesterone internal milieu is evolving.AimsTo evaluate the role of Vit D in relieving mastalgia.MethodologyPatients presenting with mastalgia were triple assessed and those presenting with clinically impalpable and radiologically benign(upto BIRAD II) were included in the study. The patients were randomly divided into 2 groups : Group A(n=79) who received EPO only and Group B (n=80)who received EPO and Vit D at a dose of 60,000 units per week over a period of 6-12 weeks. The response rates in the two groups were assessed by VAS. Results: :Total 159 patients with mastalgia were studied.79 patients treated with EPO only showed insignificant response -32, moderate response-30 and good response- 17. 80 patients treated with EPO and VIT D showed good response-56, moderate response- 16, insignificant response-8. (Response p value= 0.016.)DiscussionIncrease level of estrogen and progesterone causes ductal dilatation which is responsible for breast pain prior to the onset of menstruation. Vitamin D reduces progesterone 10% and estrogen 3% with 4ng/ml increase in vitamin D levels.ConclusionThere is an evident deficiency of vitamin D of varying degree (mild to severe) in 78 % of patients with mastalgia . Supplementation of vitamin D in mastalgia is strongly associated with reduction of breast pain .
Topic: Benign disease
Introduction:Mastalgia is the commonest reason for presentation of a female in a breast OPD. Various medicine and lifestyle modifications have been suggested with variable results. The role of Vitamin D in subtle regulation of estrogen-progesterone internal milieu is evolving.AimsTo evaluate the role of Vit D in relieving mastalgia.MethodologyPatients presenting with mastalgia were triple assessed and those presenting with clinically impalpable and radiologically benign(upto BIRAD II) were included in the study. The patients were randomly divided into 2 groups : Group A(n=79) who received EPO only and Group B (n=80)who received EPO and Vit D at a dose of 60,000 units per week over a period of 6-12 weeks. The response rates in the two groups were assessed by VAS. Results: :Total 159 patients with mastalgia were studied.79 patients treated with EPO only showed insignificant response -32, moderate response-30 and good response- 17. 80 patients treated with EPO and VIT D showed good response-56, moderate response- 16, insignificant response-8. (Response p value= 0.016.)DiscussionIncrease level of estrogen and progesterone causes ductal dilatation which is responsible for breast pain prior to the onset of menstruation. Vitamin D reduces progesterone 10% and estrogen 3% with 4ng/ml increase in vitamin D levels.ConclusionThere is an evident deficiency of vitamin D of varying degree (mild to severe) in 78 % of patients with mastalgia . Supplementation of vitamin D in mastalgia is strongly associated with reduction of breast pain .
P028
Topic: Benign disease
Introduction:Mastalgia is the commonest reason for presentation of a female in a breast OPD. Various medicine and lifestyle modifications have been suggested with variable results. The role of Vitamin D in subtle regulation of estrogen-progesterone internal milieu is evolving.AimsTo evaluate the role of Vit D in relieving mastalgia.MethodologyPatients presenting with mastalgia were triple assessed and those presenting with clinically impalpable and radiologically benign(upto BIRAD II) were included in the study. The patients were randomly divided into 2 groups : Group A(n=79) who received EPO only and Group B (n=80)who received EPO and Vit D at a dose of 60,000 units per week over a period of 6-12 weeks. The response rates in the two groups were assessed by VAS. Results: :Total 159 patients with mastalgia were studied.79 patients treated with EPO only showed insignificant response -32, moderate response-30 and good response- 17. 80 patients treated with EPO and VIT D showed good response-56, moderate response- 16, insignificant response-8. (Response p value= 0.016.)DiscussionIncrease level of estrogen and progesterone causes ductal dilatation which is responsible for breast pain prior to the onset of menstruation. Vitamin D reduces progesterone 10% and estrogen 3% with 4ng/ml increase in vitamin D levels.ConclusionThere is an evident deficiency of vitamin D of varying degree (mild to severe) in 78 % of patients with mastalgia . Supplementation of vitamin D in mastalgia is strongly associated with reduction of breast pain .
Topic: Benign disease
Introduction:Mastalgia is the commonest reason for presentation of a female in a breast OPD. Various medicine and lifestyle modifications have been suggested with variable results. The role of Vitamin D in subtle regulation of estrogen-progesterone internal milieu is evolving.AimsTo evaluate the role of Vit D in relieving mastalgia.MethodologyPatients presenting with mastalgia were triple assessed and those presenting with clinically impalpable and radiologically benign(upto BIRAD II) were included in the study. The patients were randomly divided into 2 groups : Group A(n=79) who received EPO only and Group B (n=80)who received EPO and Vit D at a dose of 60,000 units per week over a period of 6-12 weeks. The response rates in the two groups were assessed by VAS. Results: :Total 159 patients with mastalgia were studied.79 patients treated with EPO only showed insignificant response -32, moderate response-30 and good response- 17. 80 patients treated with EPO and VIT D showed good response-56, moderate response- 16, insignificant response-8. (Response p value= 0.016.)DiscussionIncrease level of estrogen and progesterone causes ductal dilatation which is responsible for breast pain prior to the onset of menstruation. Vitamin D reduces progesterone 10% and estrogen 3% with 4ng/ml increase in vitamin D levels.ConclusionThere is an evident deficiency of vitamin D of varying degree (mild to severe) in 78 % of patients with mastalgia . Supplementation of vitamin D in mastalgia is strongly associated with reduction of breast pain .
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