Clinico-pathological correlates of Triple Negative Breast Cancer and factors affecting Disease Free Survival- Experience from a tertiary care centre
Association of Breast Surgery ePoster Library. Laroiya I. 05/13/19; 257088; P044
Dr. Ishita Laroiya
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P044
Topic: Breast surgery
Introduction: Triple Negative Breast Cancer (TNBC) is an aggressive clinical subtype with different Clinicopathological features than other subtypesMethods: The clinical and pathological records, including follow up (minimum 2 years) of 220 patients with TNBC treated in the Breast Clinic at PGIMER, Chandigarh, India between 2010-2014 were reviewed. The clinico-pathological features were recorded, Disease Free Survival (DFS) calculated and correlation of standard prognostic factors with DFS was done.Result: Out of 220 patients analyzed, Stage II formed the majority- 62.2%; 46.36% were node negative. Infiltrating Ductal Carcinoma NOS was the most common pathological subtype (91.9%), higher grade tumours were more common (Grade-3-57.6%). 74/220 patients received Neoadjuvant Chemotherapy with pathological complete response rate of 37.84% .Disease Free Survival (DFS) at 5 years for the entire study population was 85.2% (80-90.7%)(DFS at 5 years 88.8% for Early Breast Cancer and 81% for Locally Advanced Breast Cancer). At average 4.4 years follow up- 31/220 (15%) of the patients had a breast cancer event.On univariate analysis Tumour Stage, Tumour Size, Pathological Nodal Status and presence of Lymphovascular Invasion (LVI) were factors significantly associated with DFS (p=0.0001;p=0.0002;p=0.0006 and p=0.041 respectively).On multivariate analysis,Tumour Size (p=0.0004) and presence of LVI (p=0.003) remained significant. Type of surgery performed (mastectomy versus breast conservation) did not make a difference to DFS (p=0.275).Conclusion: TNBC are higher grade tumours but have a higher pathological complete response rate (37.8%).Traditional prognostic factors- Tumour Stage, Tumour Size, Nodal Status and presence of LVI continue to be determinants of DFS.
Topic: Breast surgery
Introduction: Triple Negative Breast Cancer (TNBC) is an aggressive clinical subtype with different Clinicopathological features than other subtypesMethods: The clinical and pathological records, including follow up (minimum 2 years) of 220 patients with TNBC treated in the Breast Clinic at PGIMER, Chandigarh, India between 2010-2014 were reviewed. The clinico-pathological features were recorded, Disease Free Survival (DFS) calculated and correlation of standard prognostic factors with DFS was done.Result: Out of 220 patients analyzed, Stage II formed the majority- 62.2%; 46.36% were node negative. Infiltrating Ductal Carcinoma NOS was the most common pathological subtype (91.9%), higher grade tumours were more common (Grade-3-57.6%). 74/220 patients received Neoadjuvant Chemotherapy with pathological complete response rate of 37.84% .Disease Free Survival (DFS) at 5 years for the entire study population was 85.2% (80-90.7%)(DFS at 5 years 88.8% for Early Breast Cancer and 81% for Locally Advanced Breast Cancer). At average 4.4 years follow up- 31/220 (15%) of the patients had a breast cancer event.On univariate analysis Tumour Stage, Tumour Size, Pathological Nodal Status and presence of Lymphovascular Invasion (LVI) were factors significantly associated with DFS (p=0.0001;p=0.0002;p=0.0006 and p=0.041 respectively).On multivariate analysis,Tumour Size (p=0.0004) and presence of LVI (p=0.003) remained significant. Type of surgery performed (mastectomy versus breast conservation) did not make a difference to DFS (p=0.275).Conclusion: TNBC are higher grade tumours but have a higher pathological complete response rate (37.8%).Traditional prognostic factors- Tumour Stage, Tumour Size, Nodal Status and presence of LVI continue to be determinants of DFS.
P044
Topic: Breast surgery
Introduction: Triple Negative Breast Cancer (TNBC) is an aggressive clinical subtype with different Clinicopathological features than other subtypesMethods: The clinical and pathological records, including follow up (minimum 2 years) of 220 patients with TNBC treated in the Breast Clinic at PGIMER, Chandigarh, India between 2010-2014 were reviewed. The clinico-pathological features were recorded, Disease Free Survival (DFS) calculated and correlation of standard prognostic factors with DFS was done.Result: Out of 220 patients analyzed, Stage II formed the majority- 62.2%; 46.36% were node negative. Infiltrating Ductal Carcinoma NOS was the most common pathological subtype (91.9%), higher grade tumours were more common (Grade-3-57.6%). 74/220 patients received Neoadjuvant Chemotherapy with pathological complete response rate of 37.84% .Disease Free Survival (DFS) at 5 years for the entire study population was 85.2% (80-90.7%)(DFS at 5 years 88.8% for Early Breast Cancer and 81% for Locally Advanced Breast Cancer). At average 4.4 years follow up- 31/220 (15%) of the patients had a breast cancer event.On univariate analysis Tumour Stage, Tumour Size, Pathological Nodal Status and presence of Lymphovascular Invasion (LVI) were factors significantly associated with DFS (p=0.0001;p=0.0002;p=0.0006 and p=0.041 respectively).On multivariate analysis,Tumour Size (p=0.0004) and presence of LVI (p=0.003) remained significant. Type of surgery performed (mastectomy versus breast conservation) did not make a difference to DFS (p=0.275).Conclusion: TNBC are higher grade tumours but have a higher pathological complete response rate (37.8%).Traditional prognostic factors- Tumour Stage, Tumour Size, Nodal Status and presence of LVI continue to be determinants of DFS.
Topic: Breast surgery
Introduction: Triple Negative Breast Cancer (TNBC) is an aggressive clinical subtype with different Clinicopathological features than other subtypesMethods: The clinical and pathological records, including follow up (minimum 2 years) of 220 patients with TNBC treated in the Breast Clinic at PGIMER, Chandigarh, India between 2010-2014 were reviewed. The clinico-pathological features were recorded, Disease Free Survival (DFS) calculated and correlation of standard prognostic factors with DFS was done.Result: Out of 220 patients analyzed, Stage II formed the majority- 62.2%; 46.36% were node negative. Infiltrating Ductal Carcinoma NOS was the most common pathological subtype (91.9%), higher grade tumours were more common (Grade-3-57.6%). 74/220 patients received Neoadjuvant Chemotherapy with pathological complete response rate of 37.84% .Disease Free Survival (DFS) at 5 years for the entire study population was 85.2% (80-90.7%)(DFS at 5 years 88.8% for Early Breast Cancer and 81% for Locally Advanced Breast Cancer). At average 4.4 years follow up- 31/220 (15%) of the patients had a breast cancer event.On univariate analysis Tumour Stage, Tumour Size, Pathological Nodal Status and presence of Lymphovascular Invasion (LVI) were factors significantly associated with DFS (p=0.0001;p=0.0002;p=0.0006 and p=0.041 respectively).On multivariate analysis,Tumour Size (p=0.0004) and presence of LVI (p=0.003) remained significant. Type of surgery performed (mastectomy versus breast conservation) did not make a difference to DFS (p=0.275).Conclusion: TNBC are higher grade tumours but have a higher pathological complete response rate (37.8%).Traditional prognostic factors- Tumour Stage, Tumour Size, Nodal Status and presence of LVI continue to be determinants of DFS.
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