Clinico-pathological features of Synchronous Breast Cancers in Northern Ireland, 2000-2015
Association of Breast Surgery ePoster Library. Dobson G. 05/13/19; 257095; P051
Mr. Gary Dobson
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P051
Topic: Breast surgery
Introduction: The reported incidence of Synchronous Breast Cancer (SBC) is 1-3%. The optimal surgical management of these patients remains unclear, given that it has not been possible to fully characterise the relations between tumours. We present clinic-pathological data for a cohort of SBCs in Northern Ireland (NI) between 2000-2015. Methods Women diagnosed with SBC were identified from a search of the NI Cancer Registry. Histopathology reports were reviewed to identify the pathological features of tumours & biomarker expression. Clinical data on surgical procedures performed and adjuvant therapy was also collected. Results: 195 cases were studied. Mean age at diagnosis was 66 years (Range 32-93). Overall 5-year survival was 69.1%. Concordance of tumour type & biomarker expression where available are recorded in Tables 1 & 2. 102 patients (64%) had bilateral mastectomies as their initial surgical procedure, 42 had breast conserving surgery. Table 1ConcordantMissing (n)ER Status90 % (n=161)17PR Status76 % (n=97)68Her2 Status85 % (n=133)43Table 2ConcordantDisconcordantMissing (n)Overall75 % (n=130)25% (n=42)23IDC (b/l)70 % (n=121)--ILC (b/l)3 % (n=6)--Mixed (b/l)2 % (n=3)--ConclusionsA significant proportion of tumours shared pathological characteristics. Concordance of biomarker expression is similar that reported in the literature. It remains unclear how SBCs are related, although this cohort have a worse prognosis than unilateral cancers. The pathological features of tumours are not a reliable method of characterising relationships and examination of tumours at a genomic level is required to elucidate this.
Topic: Breast surgery
Introduction: The reported incidence of Synchronous Breast Cancer (SBC) is 1-3%. The optimal surgical management of these patients remains unclear, given that it has not been possible to fully characterise the relations between tumours. We present clinic-pathological data for a cohort of SBCs in Northern Ireland (NI) between 2000-2015. Methods Women diagnosed with SBC were identified from a search of the NI Cancer Registry. Histopathology reports were reviewed to identify the pathological features of tumours & biomarker expression. Clinical data on surgical procedures performed and adjuvant therapy was also collected. Results: 195 cases were studied. Mean age at diagnosis was 66 years (Range 32-93). Overall 5-year survival was 69.1%. Concordance of tumour type & biomarker expression where available are recorded in Tables 1 & 2. 102 patients (64%) had bilateral mastectomies as their initial surgical procedure, 42 had breast conserving surgery. Table 1ConcordantMissing (n)ER Status90 % (n=161)17PR Status76 % (n=97)68Her2 Status85 % (n=133)43Table 2ConcordantDisconcordantMissing (n)Overall75 % (n=130)25% (n=42)23IDC (b/l)70 % (n=121)--ILC (b/l)3 % (n=6)--Mixed (b/l)2 % (n=3)--ConclusionsA significant proportion of tumours shared pathological characteristics. Concordance of biomarker expression is similar that reported in the literature. It remains unclear how SBCs are related, although this cohort have a worse prognosis than unilateral cancers. The pathological features of tumours are not a reliable method of characterising relationships and examination of tumours at a genomic level is required to elucidate this.
P051
Topic: Breast surgery
Introduction: The reported incidence of Synchronous Breast Cancer (SBC) is 1-3%. The optimal surgical management of these patients remains unclear, given that it has not been possible to fully characterise the relations between tumours. We present clinic-pathological data for a cohort of SBCs in Northern Ireland (NI) between 2000-2015. Methods Women diagnosed with SBC were identified from a search of the NI Cancer Registry. Histopathology reports were reviewed to identify the pathological features of tumours & biomarker expression. Clinical data on surgical procedures performed and adjuvant therapy was also collected. Results: 195 cases were studied. Mean age at diagnosis was 66 years (Range 32-93). Overall 5-year survival was 69.1%. Concordance of tumour type & biomarker expression where available are recorded in Tables 1 & 2. 102 patients (64%) had bilateral mastectomies as their initial surgical procedure, 42 had breast conserving surgery. Table 1ConcordantMissing (n)ER Status90 % (n=161)17PR Status76 % (n=97)68Her2 Status85 % (n=133)43Table 2ConcordantDisconcordantMissing (n)Overall75 % (n=130)25% (n=42)23IDC (b/l)70 % (n=121)--ILC (b/l)3 % (n=6)--Mixed (b/l)2 % (n=3)--ConclusionsA significant proportion of tumours shared pathological characteristics. Concordance of biomarker expression is similar that reported in the literature. It remains unclear how SBCs are related, although this cohort have a worse prognosis than unilateral cancers. The pathological features of tumours are not a reliable method of characterising relationships and examination of tumours at a genomic level is required to elucidate this.
Topic: Breast surgery
Introduction: The reported incidence of Synchronous Breast Cancer (SBC) is 1-3%. The optimal surgical management of these patients remains unclear, given that it has not been possible to fully characterise the relations between tumours. We present clinic-pathological data for a cohort of SBCs in Northern Ireland (NI) between 2000-2015. Methods Women diagnosed with SBC were identified from a search of the NI Cancer Registry. Histopathology reports were reviewed to identify the pathological features of tumours & biomarker expression. Clinical data on surgical procedures performed and adjuvant therapy was also collected. Results: 195 cases were studied. Mean age at diagnosis was 66 years (Range 32-93). Overall 5-year survival was 69.1%. Concordance of tumour type & biomarker expression where available are recorded in Tables 1 & 2. 102 patients (64%) had bilateral mastectomies as their initial surgical procedure, 42 had breast conserving surgery. Table 1ConcordantMissing (n)ER Status90 % (n=161)17PR Status76 % (n=97)68Her2 Status85 % (n=133)43Table 2ConcordantDisconcordantMissing (n)Overall75 % (n=130)25% (n=42)23IDC (b/l)70 % (n=121)--ILC (b/l)3 % (n=6)--Mixed (b/l)2 % (n=3)--ConclusionsA significant proportion of tumours shared pathological characteristics. Concordance of biomarker expression is similar that reported in the literature. It remains unclear how SBCs are related, although this cohort have a worse prognosis than unilateral cancers. The pathological features of tumours are not a reliable method of characterising relationships and examination of tumours at a genomic level is required to elucidate this.
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