Management of Occult Breast Cancer (T0N1/2/3): What is the evidence?
Association of Breast Surgery ePoster Library. Wild J. 05/13/19; 257096; P052
John Wild
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P052
Topic: Breast surgery
Introduction: Occult breast cancer, T0N1/2/3, presenting with a palpable axillary lymph node accounts for less than 1% of all breast cancers. Due to its relative rarity there have been limited data published on it. This study aimed to systematically evaluate available data on occult breast cancer. Methods Eligible studies were identified on Medline and Embase updated to the 8th of January 2018. Studies with sufficient comparative data where included, review articles and individual case reports where excluded. Results: 46 Studies were identified. The period of analysis ranged from 1965 to 2011.Mean incidence was0.39% (Range 0.10 to 0.84%). 2078 patients with occult breast cancer were included, 931 (44.8%) were treated with mastectomy and axillary node dissection (ALND), 361 (17.4%) were treated with breast conserving surgery and ALND, 339 (16.3%) were treated with ALND alone, 75 (3.6%) were treated with breast radiotherapy and ALND and 130 (6.3%) were treated with observation alone. Survival was worse and loco regional recurrence was higher in those treated with observation of the breast alone.Analysis of mastectomy specimens revealed a primary lesion in 72.0% of cases.ConclusionThere is significant variation in treatments, though the data accrual has been conducted over large periods of time, with diagnostic options and systemic treatments evolving over this time. Treating occult breast cancer with observation is inferior to other methods. There is a need for further research into this area.
Topic: Breast surgery
Introduction: Occult breast cancer, T0N1/2/3, presenting with a palpable axillary lymph node accounts for less than 1% of all breast cancers. Due to its relative rarity there have been limited data published on it. This study aimed to systematically evaluate available data on occult breast cancer. Methods Eligible studies were identified on Medline and Embase updated to the 8th of January 2018. Studies with sufficient comparative data where included, review articles and individual case reports where excluded. Results: 46 Studies were identified. The period of analysis ranged from 1965 to 2011.Mean incidence was0.39% (Range 0.10 to 0.84%). 2078 patients with occult breast cancer were included, 931 (44.8%) were treated with mastectomy and axillary node dissection (ALND), 361 (17.4%) were treated with breast conserving surgery and ALND, 339 (16.3%) were treated with ALND alone, 75 (3.6%) were treated with breast radiotherapy and ALND and 130 (6.3%) were treated with observation alone. Survival was worse and loco regional recurrence was higher in those treated with observation of the breast alone.Analysis of mastectomy specimens revealed a primary lesion in 72.0% of cases.ConclusionThere is significant variation in treatments, though the data accrual has been conducted over large periods of time, with diagnostic options and systemic treatments evolving over this time. Treating occult breast cancer with observation is inferior to other methods. There is a need for further research into this area.
P052
Topic: Breast surgery
Introduction: Occult breast cancer, T0N1/2/3, presenting with a palpable axillary lymph node accounts for less than 1% of all breast cancers. Due to its relative rarity there have been limited data published on it. This study aimed to systematically evaluate available data on occult breast cancer. Methods Eligible studies were identified on Medline and Embase updated to the 8th of January 2018. Studies with sufficient comparative data where included, review articles and individual case reports where excluded. Results: 46 Studies were identified. The period of analysis ranged from 1965 to 2011.Mean incidence was0.39% (Range 0.10 to 0.84%). 2078 patients with occult breast cancer were included, 931 (44.8%) were treated with mastectomy and axillary node dissection (ALND), 361 (17.4%) were treated with breast conserving surgery and ALND, 339 (16.3%) were treated with ALND alone, 75 (3.6%) were treated with breast radiotherapy and ALND and 130 (6.3%) were treated with observation alone. Survival was worse and loco regional recurrence was higher in those treated with observation of the breast alone.Analysis of mastectomy specimens revealed a primary lesion in 72.0% of cases.ConclusionThere is significant variation in treatments, though the data accrual has been conducted over large periods of time, with diagnostic options and systemic treatments evolving over this time. Treating occult breast cancer with observation is inferior to other methods. There is a need for further research into this area.
Topic: Breast surgery
Introduction: Occult breast cancer, T0N1/2/3, presenting with a palpable axillary lymph node accounts for less than 1% of all breast cancers. Due to its relative rarity there have been limited data published on it. This study aimed to systematically evaluate available data on occult breast cancer. Methods Eligible studies were identified on Medline and Embase updated to the 8th of January 2018. Studies with sufficient comparative data where included, review articles and individual case reports where excluded. Results: 46 Studies were identified. The period of analysis ranged from 1965 to 2011.Mean incidence was0.39% (Range 0.10 to 0.84%). 2078 patients with occult breast cancer were included, 931 (44.8%) were treated with mastectomy and axillary node dissection (ALND), 361 (17.4%) were treated with breast conserving surgery and ALND, 339 (16.3%) were treated with ALND alone, 75 (3.6%) were treated with breast radiotherapy and ALND and 130 (6.3%) were treated with observation alone. Survival was worse and loco regional recurrence was higher in those treated with observation of the breast alone.Analysis of mastectomy specimens revealed a primary lesion in 72.0% of cases.ConclusionThere is significant variation in treatments, though the data accrual has been conducted over large periods of time, with diagnostic options and systemic treatments evolving over this time. Treating occult breast cancer with observation is inferior to other methods. There is a need for further research into this area.
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