EFFECT OF EXERCISE IN BREAST CANCER PATIENTS TAKING AROMATASE INHIBITORS
Association of Breast Surgery ePoster Library. El Zayat I. 05/13/19; 257136; P092
Dr. Ibrahim El Zayat
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P092
Topic: Non surgical treatments
Introduction: The most common breast cancers in postmenopausal women are Hormone receptor-positive tumours, and hence, the majority of these women will be expected to take Aromatase Inhibitors as part of their management. Up to 50% of post-menopausal breast cancer survivors taking AIs experience AI-associated arthralgias, or joint pain. This is a common side-effect leading to many patients stopping their AIs. This is the most common reason for the poor adherence to AIs. Physical exercise has been reported to improve tolerance to AIs, and therefore the authors conducted a systematic review of the medical literature to investigate the effectiveness of this treatment. Methods :Using the PRISMA guidelines a systematic review of the medical literature using MEDLINE, EMBASE and the Cochrane databases. Outcome measures in the search included the Brief Pain Inventory (BPI), DASH questionnaire, WOMAC index, as well as assessment of cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). Predictors of adherence using linear regression were also assessed. Results:The results of the randomised clinical trials have shown significant reduction in BPI, DASH and WOMAC pain scores, as well as overall higher aerobic exercise levels. A dose-response relationship was seen, thereby rewarding those women who exercised more with reduced joint pain.Conclusion:The results of the clinical trials have shown a positive correlation between regular exercise and reduction of AI induced arthralgias. They showed an improved physical and mental outcome, while also showing improved compliance to Aromatase Inhibitors. The relationship between differing types of physical exercise (aerobic vs anaerobic), warrants further research.
Topic: Non surgical treatments
Introduction: The most common breast cancers in postmenopausal women are Hormone receptor-positive tumours, and hence, the majority of these women will be expected to take Aromatase Inhibitors as part of their management. Up to 50% of post-menopausal breast cancer survivors taking AIs experience AI-associated arthralgias, or joint pain. This is a common side-effect leading to many patients stopping their AIs. This is the most common reason for the poor adherence to AIs. Physical exercise has been reported to improve tolerance to AIs, and therefore the authors conducted a systematic review of the medical literature to investigate the effectiveness of this treatment. Methods :Using the PRISMA guidelines a systematic review of the medical literature using MEDLINE, EMBASE and the Cochrane databases. Outcome measures in the search included the Brief Pain Inventory (BPI), DASH questionnaire, WOMAC index, as well as assessment of cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). Predictors of adherence using linear regression were also assessed. Results:The results of the randomised clinical trials have shown significant reduction in BPI, DASH and WOMAC pain scores, as well as overall higher aerobic exercise levels. A dose-response relationship was seen, thereby rewarding those women who exercised more with reduced joint pain.Conclusion:The results of the clinical trials have shown a positive correlation between regular exercise and reduction of AI induced arthralgias. They showed an improved physical and mental outcome, while also showing improved compliance to Aromatase Inhibitors. The relationship between differing types of physical exercise (aerobic vs anaerobic), warrants further research.
P092
Topic: Non surgical treatments
Introduction: The most common breast cancers in postmenopausal women are Hormone receptor-positive tumours, and hence, the majority of these women will be expected to take Aromatase Inhibitors as part of their management. Up to 50% of post-menopausal breast cancer survivors taking AIs experience AI-associated arthralgias, or joint pain. This is a common side-effect leading to many patients stopping their AIs. This is the most common reason for the poor adherence to AIs. Physical exercise has been reported to improve tolerance to AIs, and therefore the authors conducted a systematic review of the medical literature to investigate the effectiveness of this treatment. Methods :Using the PRISMA guidelines a systematic review of the medical literature using MEDLINE, EMBASE and the Cochrane databases. Outcome measures in the search included the Brief Pain Inventory (BPI), DASH questionnaire, WOMAC index, as well as assessment of cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). Predictors of adherence using linear regression were also assessed. Results:The results of the randomised clinical trials have shown significant reduction in BPI, DASH and WOMAC pain scores, as well as overall higher aerobic exercise levels. A dose-response relationship was seen, thereby rewarding those women who exercised more with reduced joint pain.Conclusion:The results of the clinical trials have shown a positive correlation between regular exercise and reduction of AI induced arthralgias. They showed an improved physical and mental outcome, while also showing improved compliance to Aromatase Inhibitors. The relationship between differing types of physical exercise (aerobic vs anaerobic), warrants further research.
Topic: Non surgical treatments
Introduction: The most common breast cancers in postmenopausal women are Hormone receptor-positive tumours, and hence, the majority of these women will be expected to take Aromatase Inhibitors as part of their management. Up to 50% of post-menopausal breast cancer survivors taking AIs experience AI-associated arthralgias, or joint pain. This is a common side-effect leading to many patients stopping their AIs. This is the most common reason for the poor adherence to AIs. Physical exercise has been reported to improve tolerance to AIs, and therefore the authors conducted a systematic review of the medical literature to investigate the effectiveness of this treatment. Methods :Using the PRISMA guidelines a systematic review of the medical literature using MEDLINE, EMBASE and the Cochrane databases. Outcome measures in the search included the Brief Pain Inventory (BPI), DASH questionnaire, WOMAC index, as well as assessment of cardiorespiratory fitness, measured maximal oxygen consumption (VO2max). Predictors of adherence using linear regression were also assessed. Results:The results of the randomised clinical trials have shown significant reduction in BPI, DASH and WOMAC pain scores, as well as overall higher aerobic exercise levels. A dose-response relationship was seen, thereby rewarding those women who exercised more with reduced joint pain.Conclusion:The results of the clinical trials have shown a positive correlation between regular exercise and reduction of AI induced arthralgias. They showed an improved physical and mental outcome, while also showing improved compliance to Aromatase Inhibitors. The relationship between differing types of physical exercise (aerobic vs anaerobic), warrants further research.
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