Does rapid access to BRCA testing change surgical decision-making in newly diagnosed breast cancer patients?
Association of Breast Surgery ePoster Library. Ain Q. 05/13/19; 257173; P131
Ms. Quratul Ain
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P131
Topic: Other
Surgeons and medical oncologists in our unit have been trained to offer “Mainstream” genetic testing for breast cancer patients meeting specific criteria, e.g. triple negative cancer at any age,any cancer under the age of 40 years.Knowing the BRCA status may help plan surgical and chemotherapy treatment.Our aim was to examine the impact on surgical decision-making. Methods :Data were collected retrospectively on female patients who had Mainstream genetic testing between 17/09/2013 and 29/07/2015. Threshold for testing was set at a 10% likelihood of carrying a mutation, but relaxed after February 2015 to a predicted 5% chance. Data collected includes whether the test results were known before surgery, and type of surgery undertaken, with a specific effort to identify whether the test result had influenced this. Results: 98 patients were tested before surgery. Mean age was 43years. 26 (27%) were found to carry a pathogenic BRCA mutation. Mean time from test initiation to result was 25 days. Summarised results shown in the table. Proposed surgical treatment was influenced in 92% of those BRCA positive patients with clear documentation of initial intent. Of the 6 patients who had breast conservation and received a BRCA positive result after surgery,2 underwent bilateral mastectomy, rather than proceeding to radiotherapy.Conclusion:Most BRCA positive patients who knew their results before surgery opted for bilateral mastectomy.Mainstream ResultsBefore SurgeryAfter SurgeryBRCA+ (n=16)BRCA- (n=55)BRC+ (n=10)BRCA-(n=17)Bilateral Mastectomy 14441Unilateral Mastectomy02306BCS228610
Topic: Other
Surgeons and medical oncologists in our unit have been trained to offer “Mainstream” genetic testing for breast cancer patients meeting specific criteria, e.g. triple negative cancer at any age,any cancer under the age of 40 years.Knowing the BRCA status may help plan surgical and chemotherapy treatment.Our aim was to examine the impact on surgical decision-making. Methods :Data were collected retrospectively on female patients who had Mainstream genetic testing between 17/09/2013 and 29/07/2015. Threshold for testing was set at a 10% likelihood of carrying a mutation, but relaxed after February 2015 to a predicted 5% chance. Data collected includes whether the test results were known before surgery, and type of surgery undertaken, with a specific effort to identify whether the test result had influenced this. Results: 98 patients were tested before surgery. Mean age was 43years. 26 (27%) were found to carry a pathogenic BRCA mutation. Mean time from test initiation to result was 25 days. Summarised results shown in the table. Proposed surgical treatment was influenced in 92% of those BRCA positive patients with clear documentation of initial intent. Of the 6 patients who had breast conservation and received a BRCA positive result after surgery,2 underwent bilateral mastectomy, rather than proceeding to radiotherapy.Conclusion:Most BRCA positive patients who knew their results before surgery opted for bilateral mastectomy.Mainstream ResultsBefore SurgeryAfter SurgeryBRCA+ (n=16)BRCA- (n=55)BRC+ (n=10)BRCA-(n=17)Bilateral Mastectomy 14441Unilateral Mastectomy02306BCS228610
P131
Topic: Other
Surgeons and medical oncologists in our unit have been trained to offer “Mainstream” genetic testing for breast cancer patients meeting specific criteria, e.g. triple negative cancer at any age,any cancer under the age of 40 years.Knowing the BRCA status may help plan surgical and chemotherapy treatment.Our aim was to examine the impact on surgical decision-making. Methods :Data were collected retrospectively on female patients who had Mainstream genetic testing between 17/09/2013 and 29/07/2015. Threshold for testing was set at a 10% likelihood of carrying a mutation, but relaxed after February 2015 to a predicted 5% chance. Data collected includes whether the test results were known before surgery, and type of surgery undertaken, with a specific effort to identify whether the test result had influenced this. Results: 98 patients were tested before surgery. Mean age was 43years. 26 (27%) were found to carry a pathogenic BRCA mutation. Mean time from test initiation to result was 25 days. Summarised results shown in the table. Proposed surgical treatment was influenced in 92% of those BRCA positive patients with clear documentation of initial intent. Of the 6 patients who had breast conservation and received a BRCA positive result after surgery,2 underwent bilateral mastectomy, rather than proceeding to radiotherapy.Conclusion:Most BRCA positive patients who knew their results before surgery opted for bilateral mastectomy.Mainstream ResultsBefore SurgeryAfter SurgeryBRCA+ (n=16)BRCA- (n=55)BRC+ (n=10)BRCA-(n=17)Bilateral Mastectomy 14441Unilateral Mastectomy02306BCS228610
Topic: Other
Surgeons and medical oncologists in our unit have been trained to offer “Mainstream” genetic testing for breast cancer patients meeting specific criteria, e.g. triple negative cancer at any age,any cancer under the age of 40 years.Knowing the BRCA status may help plan surgical and chemotherapy treatment.Our aim was to examine the impact on surgical decision-making. Methods :Data were collected retrospectively on female patients who had Mainstream genetic testing between 17/09/2013 and 29/07/2015. Threshold for testing was set at a 10% likelihood of carrying a mutation, but relaxed after February 2015 to a predicted 5% chance. Data collected includes whether the test results were known before surgery, and type of surgery undertaken, with a specific effort to identify whether the test result had influenced this. Results: 98 patients were tested before surgery. Mean age was 43years. 26 (27%) were found to carry a pathogenic BRCA mutation. Mean time from test initiation to result was 25 days. Summarised results shown in the table. Proposed surgical treatment was influenced in 92% of those BRCA positive patients with clear documentation of initial intent. Of the 6 patients who had breast conservation and received a BRCA positive result after surgery,2 underwent bilateral mastectomy, rather than proceeding to radiotherapy.Conclusion:Most BRCA positive patients who knew their results before surgery opted for bilateral mastectomy.Mainstream ResultsBefore SurgeryAfter SurgeryBRCA+ (n=16)BRCA- (n=55)BRC+ (n=10)BRCA-(n=17)Bilateral Mastectomy 14441Unilateral Mastectomy02306BCS228610
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