Can tumour infiltrating lymphocytes (TILs) predict the response of neoadjuvant chemotherapy in triple negative breast cancer?
Association of Breast Surgery ePoster Library. Ain Q. 05/13/19; 257180; P138
Ms. Quratul Ain
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P138
Topic: Other
Triple negative breast cancer (TNBC) is a heterogeneous group of tumours associated with poor prognosis. Neoadjuvant chemotherapy (NACT) is recommended for stage2/3 and some stage1 disease..However,only 30-35% of TNBCs achieve pathological complete response(pCR).Tumour-infiltrating lymphocytes (TIL) have been proposed as an independent prognostic marker for TNBCs. Aim of our study was to examine if TIL can predict response to NACT. Methods :TNBC patients who had NACT between January2013 and March2017 were identified retrospectively.TILs levels were evaluated in core biopsy and post-NACT excision sections as per recommendations by International TILs Working Group 2014.Stromal TILs were categorised as low(<10%),intermediate(10-50%) and high(>50%) in pre and post therapy slides.Primary end point was to assess pathologic response to NACT. Results: 156 patients had TNBC.21(13%) patients had neoadjuvant chemotherapy.Mean age at diagnosis was 50 years. 8(38%) had low, 10(48%) intermediate and 3(14%) had high level of stromal TILs on core biopsy.Of patients with <10% TILs,1(13%) showed pCR,6(75%) had partial and 1(13%) showed no response to NACT. Patients with 10-50%TILs, 1(10%) achieved pCR,7(70%) showed partial and 2(20%) had no response.Patients who had >50% TILs at diagnosis,2(67%) achieved partial response and 1(33%) no response.Conclusion:TNBC patients with low and intermediate levels of TILs showed very identical response to NACT.TILs >50% showed a poorer response overall. The numbers in our groups are very small to reach a definite conclusion and more extensive inter-hospital study is to be planned.
Topic: Other
Triple negative breast cancer (TNBC) is a heterogeneous group of tumours associated with poor prognosis. Neoadjuvant chemotherapy (NACT) is recommended for stage2/3 and some stage1 disease..However,only 30-35% of TNBCs achieve pathological complete response(pCR).Tumour-infiltrating lymphocytes (TIL) have been proposed as an independent prognostic marker for TNBCs. Aim of our study was to examine if TIL can predict response to NACT. Methods :TNBC patients who had NACT between January2013 and March2017 were identified retrospectively.TILs levels were evaluated in core biopsy and post-NACT excision sections as per recommendations by International TILs Working Group 2014.Stromal TILs were categorised as low(<10%),intermediate(10-50%) and high(>50%) in pre and post therapy slides.Primary end point was to assess pathologic response to NACT. Results: 156 patients had TNBC.21(13%) patients had neoadjuvant chemotherapy.Mean age at diagnosis was 50 years. 8(38%) had low, 10(48%) intermediate and 3(14%) had high level of stromal TILs on core biopsy.Of patients with <10% TILs,1(13%) showed pCR,6(75%) had partial and 1(13%) showed no response to NACT. Patients with 10-50%TILs, 1(10%) achieved pCR,7(70%) showed partial and 2(20%) had no response.Patients who had >50% TILs at diagnosis,2(67%) achieved partial response and 1(33%) no response.Conclusion:TNBC patients with low and intermediate levels of TILs showed very identical response to NACT.TILs >50% showed a poorer response overall. The numbers in our groups are very small to reach a definite conclusion and more extensive inter-hospital study is to be planned.
P138
Topic: Other
Triple negative breast cancer (TNBC) is a heterogeneous group of tumours associated with poor prognosis. Neoadjuvant chemotherapy (NACT) is recommended for stage2/3 and some stage1 disease..However,only 30-35% of TNBCs achieve pathological complete response(pCR).Tumour-infiltrating lymphocytes (TIL) have been proposed as an independent prognostic marker for TNBCs. Aim of our study was to examine if TIL can predict response to NACT. Methods :TNBC patients who had NACT between January2013 and March2017 were identified retrospectively.TILs levels were evaluated in core biopsy and post-NACT excision sections as per recommendations by International TILs Working Group 2014.Stromal TILs were categorised as low(<10%),intermediate(10-50%) and high(>50%) in pre and post therapy slides.Primary end point was to assess pathologic response to NACT. Results: 156 patients had TNBC.21(13%) patients had neoadjuvant chemotherapy.Mean age at diagnosis was 50 years. 8(38%) had low, 10(48%) intermediate and 3(14%) had high level of stromal TILs on core biopsy.Of patients with <10% TILs,1(13%) showed pCR,6(75%) had partial and 1(13%) showed no response to NACT. Patients with 10-50%TILs, 1(10%) achieved pCR,7(70%) showed partial and 2(20%) had no response.Patients who had >50% TILs at diagnosis,2(67%) achieved partial response and 1(33%) no response.Conclusion:TNBC patients with low and intermediate levels of TILs showed very identical response to NACT.TILs >50% showed a poorer response overall. The numbers in our groups are very small to reach a definite conclusion and more extensive inter-hospital study is to be planned.
Topic: Other
Triple negative breast cancer (TNBC) is a heterogeneous group of tumours associated with poor prognosis. Neoadjuvant chemotherapy (NACT) is recommended for stage2/3 and some stage1 disease..However,only 30-35% of TNBCs achieve pathological complete response(pCR).Tumour-infiltrating lymphocytes (TIL) have been proposed as an independent prognostic marker for TNBCs. Aim of our study was to examine if TIL can predict response to NACT. Methods :TNBC patients who had NACT between January2013 and March2017 were identified retrospectively.TILs levels were evaluated in core biopsy and post-NACT excision sections as per recommendations by International TILs Working Group 2014.Stromal TILs were categorised as low(<10%),intermediate(10-50%) and high(>50%) in pre and post therapy slides.Primary end point was to assess pathologic response to NACT. Results: 156 patients had TNBC.21(13%) patients had neoadjuvant chemotherapy.Mean age at diagnosis was 50 years. 8(38%) had low, 10(48%) intermediate and 3(14%) had high level of stromal TILs on core biopsy.Of patients with <10% TILs,1(13%) showed pCR,6(75%) had partial and 1(13%) showed no response to NACT. Patients with 10-50%TILs, 1(10%) achieved pCR,7(70%) showed partial and 2(20%) had no response.Patients who had >50% TILs at diagnosis,2(67%) achieved partial response and 1(33%) no response.Conclusion:TNBC patients with low and intermediate levels of TILs showed very identical response to NACT.TILs >50% showed a poorer response overall. The numbers in our groups are very small to reach a definite conclusion and more extensive inter-hospital study is to be planned.
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