Postoperative wound complications after immediate breast reconstruction increase recurrence rate in ER negative patients
Association of Breast Surgery ePoster Library. Romics L. 05/13/19; 257184; P142
Mr. Laszlo Romics
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P142
Topic: Recurrent disease
Introduction: Postoperative complications may affect oncological outcomes after breast cancer surgery due to possible cross-talk between the pro-inflammatory and carcinogenic signaling pathways.Hence, we investigated whether post-operative wound complications following mastectomy and immediate reconstruction (M+IR) were associated with oncological outcomes. Methods :Patients who underwent M+IR for primary breast cancer between January 2008 and December 2012 in Canniesburn plastic surgical unit were included. Reconstruction type, pathological and complication details, and oncological outcomes were obtained retrospectively. Kaplan Meier and Cox regression survival analyses were carried out for recurrence and cancer specific death. Results: Altogether578 patients had M+IR during the study period. Of those 108 had ER negative, 386 had ER positive breast cancer, and 84 had DCIS. Median age was 51 years (27-80). 428 (74%) reconstructions were autologous, 27 (4.7%) were autologous with implant, and 123 (21.3%) were implant only. Median follow up was 66 months (3-109). There were 85 (14.7%) recurrences and 45 (7.8%) cancer deaths. There were no significant differences in patients' demographics or tumour characteristics in between patients with or without complications. In ER negative disease (n=108; 33 (30.5%) complications) presence of a wound complication was associated with increased recurrence (HR 2.38, 95%CI 1.13-4.98, p=0.022). Conversely, in ER positive disease (n=386; 136 (35.2%) complications), wound complication did not increase recurrence rate after M+IR (HR 1.12,95%CI0.63-1.99, p=0.703).Conclusion: Postoperative wound complication after M+IR may have a different impact on breast cancer recurrence in ER negative versus ER positive disease.
Topic: Recurrent disease
Introduction: Postoperative complications may affect oncological outcomes after breast cancer surgery due to possible cross-talk between the pro-inflammatory and carcinogenic signaling pathways.Hence, we investigated whether post-operative wound complications following mastectomy and immediate reconstruction (M+IR) were associated with oncological outcomes. Methods :Patients who underwent M+IR for primary breast cancer between January 2008 and December 2012 in Canniesburn plastic surgical unit were included. Reconstruction type, pathological and complication details, and oncological outcomes were obtained retrospectively. Kaplan Meier and Cox regression survival analyses were carried out for recurrence and cancer specific death. Results: Altogether578 patients had M+IR during the study period. Of those 108 had ER negative, 386 had ER positive breast cancer, and 84 had DCIS. Median age was 51 years (27-80). 428 (74%) reconstructions were autologous, 27 (4.7%) were autologous with implant, and 123 (21.3%) were implant only. Median follow up was 66 months (3-109). There were 85 (14.7%) recurrences and 45 (7.8%) cancer deaths. There were no significant differences in patients' demographics or tumour characteristics in between patients with or without complications. In ER negative disease (n=108; 33 (30.5%) complications) presence of a wound complication was associated with increased recurrence (HR 2.38, 95%CI 1.13-4.98, p=0.022). Conversely, in ER positive disease (n=386; 136 (35.2%) complications), wound complication did not increase recurrence rate after M+IR (HR 1.12,95%CI0.63-1.99, p=0.703).Conclusion: Postoperative wound complication after M+IR may have a different impact on breast cancer recurrence in ER negative versus ER positive disease.
P142
Topic: Recurrent disease
Introduction: Postoperative complications may affect oncological outcomes after breast cancer surgery due to possible cross-talk between the pro-inflammatory and carcinogenic signaling pathways.Hence, we investigated whether post-operative wound complications following mastectomy and immediate reconstruction (M+IR) were associated with oncological outcomes. Methods :Patients who underwent M+IR for primary breast cancer between January 2008 and December 2012 in Canniesburn plastic surgical unit were included. Reconstruction type, pathological and complication details, and oncological outcomes were obtained retrospectively. Kaplan Meier and Cox regression survival analyses were carried out for recurrence and cancer specific death. Results: Altogether578 patients had M+IR during the study period. Of those 108 had ER negative, 386 had ER positive breast cancer, and 84 had DCIS. Median age was 51 years (27-80). 428 (74%) reconstructions were autologous, 27 (4.7%) were autologous with implant, and 123 (21.3%) were implant only. Median follow up was 66 months (3-109). There were 85 (14.7%) recurrences and 45 (7.8%) cancer deaths. There were no significant differences in patients' demographics or tumour characteristics in between patients with or without complications. In ER negative disease (n=108; 33 (30.5%) complications) presence of a wound complication was associated with increased recurrence (HR 2.38, 95%CI 1.13-4.98, p=0.022). Conversely, in ER positive disease (n=386; 136 (35.2%) complications), wound complication did not increase recurrence rate after M+IR (HR 1.12,95%CI0.63-1.99, p=0.703).Conclusion: Postoperative wound complication after M+IR may have a different impact on breast cancer recurrence in ER negative versus ER positive disease.
Topic: Recurrent disease
Introduction: Postoperative complications may affect oncological outcomes after breast cancer surgery due to possible cross-talk between the pro-inflammatory and carcinogenic signaling pathways.Hence, we investigated whether post-operative wound complications following mastectomy and immediate reconstruction (M+IR) were associated with oncological outcomes. Methods :Patients who underwent M+IR for primary breast cancer between January 2008 and December 2012 in Canniesburn plastic surgical unit were included. Reconstruction type, pathological and complication details, and oncological outcomes were obtained retrospectively. Kaplan Meier and Cox regression survival analyses were carried out for recurrence and cancer specific death. Results: Altogether578 patients had M+IR during the study period. Of those 108 had ER negative, 386 had ER positive breast cancer, and 84 had DCIS. Median age was 51 years (27-80). 428 (74%) reconstructions were autologous, 27 (4.7%) were autologous with implant, and 123 (21.3%) were implant only. Median follow up was 66 months (3-109). There were 85 (14.7%) recurrences and 45 (7.8%) cancer deaths. There were no significant differences in patients' demographics or tumour characteristics in between patients with or without complications. In ER negative disease (n=108; 33 (30.5%) complications) presence of a wound complication was associated with increased recurrence (HR 2.38, 95%CI 1.13-4.98, p=0.022). Conversely, in ER positive disease (n=386; 136 (35.2%) complications), wound complication did not increase recurrence rate after M+IR (HR 1.12,95%CI0.63-1.99, p=0.703).Conclusion: Postoperative wound complication after M+IR may have a different impact on breast cancer recurrence in ER negative versus ER positive disease.
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