ABS ePoster Library

P144
Topic: Recurrent disease

Introduction: Breast cancer recurrence is a rare but serious outcome following curative surgery. Risk scoring systems can provide an inexpensive and accessible way to identify at-risk patients but had not been validated within our local population. Methods We performed retrospective service evaluation to determine whether commonly referenced risk factors were associated with breast cancer recurrence at Bedford Hospital. Permission was obtained from the Bedford Hospital Audit Committee. Patients who underwent surgical management between 2003 and 2013 were identified from Somerset Integrated Digital electronic Records (SIDeR). Controls were randomly selected on a 4:1 ratio. Factors classically associated with breast cancer recurrence were collected from case records; these included age, grade, size of tumour, invasion status and choice of adjuvant therapy. Medcalc Version 18.11 was used to perform multiple regression analysis. Results: A total of 2537 patients were surgically treated for breast cancer with 56 patients presenting with recurrence within 5 years of surgery. Diameter of tumour was associated with increased risk of recurrence (Beta= 0.002, p=0.013). Treatment with radiotherapy (Beta= -0.287, p<0.0001) and invasion status (Beta= -0.778, p<0.0001) were associated with a reduced risk of recurrence.ConclusionWhilst associations of tumour size and radiotherapy treatment are concurrent with the literature, a reduced risk of recurrence in invasive cases has not previously been identified. Our study provides a preliminary insight into a pragmatically analysed, local data set. Further analysis of the treatment protocol forpatients with non-invasive cancer is warranted.