Study of breast cancer presentation and triple negative status in Bangladeshi women resident in the UK compared to those living in Bangladesh
Association of Breast Surgery ePoster Library. Awad A. 05/13/19; 257188; P146
Dr. Amine Awad
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P146
Topic: Risk factors for breast cancer
Introduction: There are significant differences in breast cancer affecting women in Bangladesh and in the United Kingdom(UK). For women in Bangladesh, age at diagnosis is a decade earlier, on average, and reported rates of triple negative breast cancer are as high as 27% compared to 15% in the UK. It's unclear to what extent environmental, genetic, and social factors underlie these differences. This study aimed to assess whether country of residence had an effect on breast tumour characteristics among women of Bangladeshi ethnic origin. Methods :A cohort of British-Bangladeshi patients diagnosed at Barts Health NHS Trust (n=179), and a cohort of Bangladeshi patients diagnosed at a single centre in Bangladesh (n=48) were identified. Patient medical records were retrospectively reviewed for data on age at diagnosis and triple receptor status. A two-tailed t test was used to analyse differences in age at diagnosis. A chi-squared test was used to analyse differences in rates of triple negative breast cancer. Results: Mean age at diagnosis for all breast cancers was higher in the British-Bangladeshi cohort compared to native Bangladeshis (50.98 vs. 44.80; p<0.001). Mean age at diagnosis for triple negative cancer, however, was similar (46.00 vs. 46.18; p=0.95). Percentage of triple negative disease was lower in the British-Bangladeshi cohort (17.5% vs. 30.6%; Χ2=0.047). Conclusions: Triple negative cancer rates among British-Bangladeshis closely approximate reported rates in the UK. This suggests that environmental and lifestyle factors may be of greater importance in driving the higher rates of triple negative breast cancer seen in Bangladesh.
Topic: Risk factors for breast cancer
Introduction: There are significant differences in breast cancer affecting women in Bangladesh and in the United Kingdom(UK). For women in Bangladesh, age at diagnosis is a decade earlier, on average, and reported rates of triple negative breast cancer are as high as 27% compared to 15% in the UK. It's unclear to what extent environmental, genetic, and social factors underlie these differences. This study aimed to assess whether country of residence had an effect on breast tumour characteristics among women of Bangladeshi ethnic origin. Methods :A cohort of British-Bangladeshi patients diagnosed at Barts Health NHS Trust (n=179), and a cohort of Bangladeshi patients diagnosed at a single centre in Bangladesh (n=48) were identified. Patient medical records were retrospectively reviewed for data on age at diagnosis and triple receptor status. A two-tailed t test was used to analyse differences in age at diagnosis. A chi-squared test was used to analyse differences in rates of triple negative breast cancer. Results: Mean age at diagnosis for all breast cancers was higher in the British-Bangladeshi cohort compared to native Bangladeshis (50.98 vs. 44.80; p<0.001). Mean age at diagnosis for triple negative cancer, however, was similar (46.00 vs. 46.18; p=0.95). Percentage of triple negative disease was lower in the British-Bangladeshi cohort (17.5% vs. 30.6%; Χ2=0.047). Conclusions: Triple negative cancer rates among British-Bangladeshis closely approximate reported rates in the UK. This suggests that environmental and lifestyle factors may be of greater importance in driving the higher rates of triple negative breast cancer seen in Bangladesh.
P146
Topic: Risk factors for breast cancer
Introduction: There are significant differences in breast cancer affecting women in Bangladesh and in the United Kingdom(UK). For women in Bangladesh, age at diagnosis is a decade earlier, on average, and reported rates of triple negative breast cancer are as high as 27% compared to 15% in the UK. It's unclear to what extent environmental, genetic, and social factors underlie these differences. This study aimed to assess whether country of residence had an effect on breast tumour characteristics among women of Bangladeshi ethnic origin. Methods :A cohort of British-Bangladeshi patients diagnosed at Barts Health NHS Trust (n=179), and a cohort of Bangladeshi patients diagnosed at a single centre in Bangladesh (n=48) were identified. Patient medical records were retrospectively reviewed for data on age at diagnosis and triple receptor status. A two-tailed t test was used to analyse differences in age at diagnosis. A chi-squared test was used to analyse differences in rates of triple negative breast cancer. Results: Mean age at diagnosis for all breast cancers was higher in the British-Bangladeshi cohort compared to native Bangladeshis (50.98 vs. 44.80; p<0.001). Mean age at diagnosis for triple negative cancer, however, was similar (46.00 vs. 46.18; p=0.95). Percentage of triple negative disease was lower in the British-Bangladeshi cohort (17.5% vs. 30.6%; Χ2=0.047). Conclusions: Triple negative cancer rates among British-Bangladeshis closely approximate reported rates in the UK. This suggests that environmental and lifestyle factors may be of greater importance in driving the higher rates of triple negative breast cancer seen in Bangladesh.
Topic: Risk factors for breast cancer
Introduction: There are significant differences in breast cancer affecting women in Bangladesh and in the United Kingdom(UK). For women in Bangladesh, age at diagnosis is a decade earlier, on average, and reported rates of triple negative breast cancer are as high as 27% compared to 15% in the UK. It's unclear to what extent environmental, genetic, and social factors underlie these differences. This study aimed to assess whether country of residence had an effect on breast tumour characteristics among women of Bangladeshi ethnic origin. Methods :A cohort of British-Bangladeshi patients diagnosed at Barts Health NHS Trust (n=179), and a cohort of Bangladeshi patients diagnosed at a single centre in Bangladesh (n=48) were identified. Patient medical records were retrospectively reviewed for data on age at diagnosis and triple receptor status. A two-tailed t test was used to analyse differences in age at diagnosis. A chi-squared test was used to analyse differences in rates of triple negative breast cancer. Results: Mean age at diagnosis for all breast cancers was higher in the British-Bangladeshi cohort compared to native Bangladeshis (50.98 vs. 44.80; p<0.001). Mean age at diagnosis for triple negative cancer, however, was similar (46.00 vs. 46.18; p=0.95). Percentage of triple negative disease was lower in the British-Bangladeshi cohort (17.5% vs. 30.6%; Χ2=0.047). Conclusions: Triple negative cancer rates among British-Bangladeshis closely approximate reported rates in the UK. This suggests that environmental and lifestyle factors may be of greater importance in driving the higher rates of triple negative breast cancer seen in Bangladesh.
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